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Disp3 dispatched RND transporter family member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313705, updated on 4-Jan-2025

Summary

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Official Symbol
Disp3provided by RGD
Official Full Name
dispatched RND transporter family member 3provided by RGD
Primary source
RGD:1305820
See related
EnsemblRapid:ENSRNOG00000026447 AllianceGenome:RGD:1305820
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ptchd2; RGD1305820
Summary
Predicted to be involved in negative regulation of neuron differentiation; positive regulation of lipid metabolic process; and positive regulation of neural precursor cell proliferation. Predicted to be located in membrane. Predicted to be active in cytoplasm. Orthologous to human DISP3 (dispatched RND transporter family member 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward (RPKM 27.2) See more
Orthologs
human mouse all
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Genomic context

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See Disp3 in Genome Data Viewer
Location:
5q36
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (163955160..164003980, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (158672015..158720806, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (165051522..165099826, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene F-box protein 2 Neighboring gene uncharacterized LOC108351059 Neighboring gene uncharacterized LOC102551951 Neighboring gene UbiA prenyltransferase domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. DISP3 promotes proliferation and delays differentiation of neural progenitor cells. Zíková M, et al. FEBS Lett, 2014 Nov 3. PMID 25281927
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of lipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neural precursor cell proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein dispatched homolog 3
Names
patched domain containing 2
patched domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107992.2 → NP_001101462.2  protein dispatched homolog 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    D3ZW02
    Related
    ENSRNOP00000037381.6, ENSRNOT00000036647.8
    Conserved Domains (1) summary
    COG1033
    Location:375 → 572
    COG1033; Predicted exporter protein, RND superfamily [General function prediction only]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    163955160..164003980 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110097.2 → XP_038966025.1  protein dispatched homolog 3 isoform X1

    Conserved Domains (1) summary
    COG1033
    Location:375 → 572
    COG1033; Predicted exporter protein, RND superfamily [General function prediction only]

RNA

  1. XR_005504461.2 RNA Sequence

  2. XR_005504462.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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