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Xpac Xeroderma pigmentosum group A-like [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31357, updated on 9-Dec-2024

Summary

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Official Symbol
Xpacprovided by FlyBase
Official Full Name
Xeroderma pigmentosum group A-likeprovided by FlyBase
Primary source
FLYBASE:FBgn0004832
Locus tag
Dmel_CG6358
See related
AllianceGenome:FB:FBgn0004832
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6358; DhR14; DhXPA; Dmel\CG6358; dmXPA; DmXPA; dxpa; Dxpa; EG:EG0007.8; Xpa; XPA; XPAC; XPA_DROME
Summary
Predicted to enable damaged DNA binding activity. Involved in nucleotide-excision repair. Located in nucleus. Is expressed in several structures, including adult central nervous system; lamina; larval ventral nerve cord; muscle cell; and retina. Human ortholog(s) of this gene implicated in xeroderma pigmentosum and xeroderma pigmentosum group A. Orthologous to human XPA (XPA, DNA damage recognition and repair factor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Xpac in Genome Data Viewer
Location:
4A5-4A5; 1-6 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4102955..4104197, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (3996988..3998230, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Cap methyltransferase 1 Neighboring gene uncharacterized protein Neighboring gene brainiac Neighboring gene ciboulot

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cross-species investigation into the requirement of XPA for nucleotide excision repair. Kose C, et al. Nucleic Acids Res, 2024 Jan 25. PMID 37994737, Free PMC Article
  2. Expression and functional analyses of the Dxpa gene, the Drosophila homolog of the human excision repair gene XPA. Shimamoto T, et al. J Biol Chem, 1995 Sep 22. PMID 7673233
  3. Molecular cloning of human XPAC gene homologs from chicken, Xenopus laevis and Drosophila melanogaster. Shimamoto T, et al. Biochem Biophys Res Commun, 1991 Dec 31. PMID 1764072
  4. Ciboulot regulates actin assembly during Drosophila brain metamorphosis. Boquet I, et al. Cell, 2000 Sep 15. PMID 11030623
  5. Cellular responses to DNA damage in Drosophila melanogaster. Dusenbery RL, et al. Mutat Res, 1996 Dec 2. PMID 8960126

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables damaged DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables damaged DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in UV-damage excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in base-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide-excision repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleotide-excision repair IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nucleotide-excision repair involved in interstrand cross-link repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide-excision repair, DNA damage recognition IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of nucleotide-excision repair factor 1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
xeroderma pigmentosum group A-like
Names
CG6358-PA
Xpac-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    4102955..4104197 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057518.4 → NP_476866.1  xeroderma pigmentosum group A-like [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476866.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P28518, Q24594, Q9V3V8
    UniProtKB/TrEMBL
    D3PFI1, H0RNH2
    Related
    FBpp0070638
    Conserved Domains (3) summary
    TIGR00598
    Location:126 → 296
    rad14; DNA repair protein
    pfam01286
    Location:125 → 154
    XPA_N; XPA protein N-terminal
    pfam05181
    Location:156 → 207
    XPA_C; XPA protein C-terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P28518.3 P28518

Gene LinkOut

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