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Foxj3 forkhead box J3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313554, updated on 4-Jan-2025

Summary

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Official Symbol
Foxj3provided by RGD
Official Full Name
forkhead box J3provided by RGD
Primary source
RGD:1311770
See related
EnsemblRapid:ENSRNOG00000061851 AllianceGenome:RGD:1311770
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in male meiosis I; positive regulation of transcription by RNA polymerase II; and spermatogenesis. Predicted to be active in nucleus. Orthologous to human FOXJ3 (forkhead box J3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Muscle (RPKM 77.4), Heart (RPKM 72.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Foxj3 in Genome Data Viewer
Location:
5q36
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (138425623..138513760)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (133140344..133228489)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (138587968..138676948)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene zinc finger, MYND-type containing 12 Neighboring gene ribosomal modification protein rimK-like family member A Neighboring gene ribosomal protein S27a, pseudogene 1 Neighboring gene ubiquitin-like FUBI-ribosomal protein eS30 fusion protein Neighboring gene guanylate cyclase activator 2A Neighboring gene guanylate cyclase activator 2B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Live-cell monitoring of periodic gene expression in synchronous human cells identifies Forkhead genes involved in cell cycle control. Grant GD, et al. Mol Biol Cell, 2012 Aug. PMID 22740631, Free PMC Article
  2. DNA-binding specificities of human transcription factors. Jolma A, et al. Cell, 2013 Jan 17. PMID 23332764
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in male meiosis I ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
forkhead box protein J3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107971.4 → NP_001101441.1  forkhead box protein J3

    See identical proteins and their annotated locations for NP_001101441.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A0G2JWM4, A6JZP5
    Conserved Domains (2) summary
    COG5025
    Location:54 → 345
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    cd20052
    Location:77 → 155
    FH_FOXJ3; Forkhead (FH) domain found in Forkhead box protein J3 (FOXJ3) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    138425623..138513760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110006.1 → XP_038965934.1  forkhead box protein J3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JWM4, A6JZP5
    Conserved Domains (2) summary
    COG5025
    Location:54 → 345
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    cd20052
    Location:77 → 155
    FH_FOXJ3; Forkhead (FH) domain found in Forkhead box protein J3 (FOXJ3) and similar proteins

  2. XM_039110009.1 → XP_038965937.1  forkhead box protein J3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AQ64
    Conserved Domains (2) summary
    COG5025
    Location:54 → 311
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    cd20024
    Location:78 → 154
    FH_FOXJ2-like; Forkhead (FH) domain found in Forkhead box proteins, FOXJ2, FOXJ3 and similar proteins

  3. XM_039110007.1 → XP_038965935.1  forkhead box protein J3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JWM4, A6JZP5
    Related
    ENSRNOP00000096130.2, ENSRNOT00000103629.2
    Conserved Domains (2) summary
    COG5025
    Location:54 → 345
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    cd20052
    Location:77 → 155
    FH_FOXJ3; Forkhead (FH) domain found in Forkhead box protein J3 (FOXJ3) and similar proteins

  4. XM_063287744.1 → XP_063143814.1  forkhead box protein J3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AQ64

  5. XM_039110008.2 → XP_038965936.1  forkhead box protein J3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JWM4, A6JZP5
    Related
    ENSRNOP00000069938.3, ENSRNOT00000083754.3
    Conserved Domains (2) summary
    COG5025
    Location:54 → 345
    COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    cd20052
    Location:77 → 155
    FH_FOXJ3; Forkhead (FH) domain found in Forkhead box protein J3 (FOXJ3) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version

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