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B4galt2 beta-1,4-galactosyltransferase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313536, updated on 2-Nov-2024

Summary

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Official Symbol
B4galt2provided by RGD
Official Full Name
beta-1,4-galactosyltransferase 2provided by RGD
Primary source
RGD:1305358
See related
EnsemblRapid:ENSRNOG00000019609 AllianceGenome:RGD:1305358
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable galactosyltransferase activity. Predicted to be involved in glycosylation. Predicted to act upstream of or within cerebellar Purkinje cell layer development; learning or memory; and locomotory behavior. Predicted to be located in nucleoplasm. Predicted to be active in Golgi apparatus. Orthologous to human B4GALT2 (beta-1,4-galactosyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 84.6), Lung (RPKM 31.3) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See B4galt2 in Genome Data Viewer
Location:
5q36
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (136697981..136707783, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (131412541..131422573, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (136707510..136717345, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene KLF transcription factor 17 Neighboring gene solute carrier family 6 member 9 Neighboring gene coiled-coil domain containing 24 Neighboring gene uncharacterized LOC120102957 Neighboring gene ATPase H+ transporting V0 subunit B Neighboring gene diphthamide biosynthesis 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Learning/memory impairment and reduced expression of the HNK-1 carbohydrate in beta4-galactosyltransferase-II-deficient mice. Yoshihara T, et al. J Biol Chem, 2009 May 1. PMID 19265195, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables galactosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within brain development ISO
Inferred from Sequence Orthology
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cerebellar Purkinje cell layer development ISO
Inferred from Sequence Orthology
more info
  
involved_in glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within locomotory behavior ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within memory ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within visual learning ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
beta-1,4-galactosyltransferase 2
Names
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
NP_001101435.1
XP_006238729.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107965.1 → NP_001101435.1  beta-1,4-galactosyltransferase 2

    See identical proteins and their annotated locations for NP_001101435.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474008
    UniProtKB/TrEMBL
    A6JZE9, D4A2A5
    Related
    ENSRNOP00000026591.4, ENSRNOT00000026591.8
    Conserved Domains (1) summary
    cd00899
    Location:142 → 358
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    136697981..136707783 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006238667.5 → XP_006238729.1  beta-1,4-galactosyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_006238729.1

    UniProtKB/TrEMBL
    A6JZE9, D4A2A5
    Conserved Domains (1) summary
    cd00899
    Location:142 → 358
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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