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CG43689 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31353, updated on 9-Dec-2024

Summary

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Official Symbol
CG43689provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0263772
Locus tag
Dmel_CG43689
See related
AllianceGenome:FB:FBgn0263772
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15376; CG32778; CG32790; CG43284; CG4985; Dmel\CG43689
Old locus tag
Dmel_CG15376; Dmel_CG32778; Dmel_CG32790; Dmel_CG43284
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 39. Orthologous to human ST18 (ST18 C2H2C-type zinc finger transcription factor); MYT1 (myelin transcription factor 1); and MYT1L (myelin transcription factor 1 like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG43689 in Genome Data Viewer
Location:
4A4-4A5; 1-6 cM
Exon count:
14
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4075743..4092237)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (3970011..3986270)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46247 Neighboring gene long non-coding RNA:CR46349 Neighboring gene Cap methyltransferase 1 Neighboring gene uncharacterized protein Neighboring gene Xeroderma pigmentosum group A-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-wide in vitro and in vivo RNAi screens reveal Fer3 to be an important regulator of kkv transcription in Drosophila. Yue X, et al. Insect Sci, 2022 Jun. PMID 34351065
  2. A transcriptomic taxonomy of Drosophila circadian neurons around the clock. Ma D, et al. Elife, 2021 Jan 13. PMID 33438579, Free PMC Article
  3. The transcriptional diversity of 25 Drosophila cell lines. Cherbas L, et al. Genome Res, 2011 Feb. PMID 21177962, Free PMC Article
  4. Temporal evolution of single-cell transcriptomes of Drosophila olfactory projection neurons. Xie Q, et al. Elife, 2021 Jan 11. PMID 33427646, Free PMC Article
  5. Single-cell transcriptomes of developing and adult olfactory receptor neurons in Drosophila. McLaughlin CN, et al. Elife, 2021 Feb 8. PMID 33555999, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG43689-PC
CG43689-PD
CG43689-PE
CG43689-PF
CG43689-PG
CG43689-PH
CG43689-PI

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    4075743..4092237
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001370021.1 → NP_001356932.1  uncharacterized protein Dmel_CG43689, isoform I [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PGM4
    Conserved Domains (1) summary
    pfam01530
    Location:1108 → 1136
    zf-C2HC; Zinc finger, C2HC type

  2. NM_001297921.1 → NP_001284850.1  uncharacterized protein Dmel_CG43689, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284850.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JCH4
    Conserved Domains (1) summary
    pfam01530
    Location:1078 → 1104
    zf-C2HC; Zinc finger, C2HC type

  3. NM_001272301.2 → NP_001259230.1  uncharacterized protein Dmel_CG43689, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259230.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PJ12
    Conserved Domains (1) summary
    pfam01530
    Location:1166 → 1192
    zf-C2HC; Zinc finger, C2HC type

  4. NM_001272300.2 → NP_001259229.1  uncharacterized protein Dmel_CG43689, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259229.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PGM4
    Conserved Domains (1) summary
    pfam01530
    Location:1108 → 1136
    zf-C2HC; Zinc finger, C2HC type

  5. NM_001272298.2 → NP_001259227.1  uncharacterized protein Dmel_CG43689, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259227.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PGE8
    Conserved Domains (1) summary
    pfam01530
    Location:1108 → 1134
    zf-C2HC; Zinc finger, C2HC type

  6. NM_001272299.2 → NP_001259228.1  uncharacterized protein Dmel_CG43689, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259228.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PH00
    Conserved Domains (1) summary
    pfam01530
    Location:1189 → 1215
    zf-C2HC; Zinc finger, C2HC type

  7. NM_167000.4 → NP_726905.2  uncharacterized protein Dmel_CG43689, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726905.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W4N4
    Conserved Domains (1) summary
    pfam01530
    Location:1166 → 1192
    zf-C2HC; Zinc finger, C2HC type
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PGE8 M9PGE8
M9PGM4 M9PGM4
M9PH00 M9PH00
M9PJ12 M9PJ12
Q9W4N4 Q9W4N4
X2JCH4 X2JCH4

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