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Glos Gaulos [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31348, updated on 4-Jan-2025

Summary

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Official Symbol
Glosprovided by FlyBase
Official Full Name
Gaulosprovided by FlyBase
Primary source
FLYBASE:FBgn0029686
Locus tag
Dmel_CG2941
See related
AllianceGenome:FB:FBgn0029686
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2941; Dmel\CG2941; Gem4; Gem4a; GEMIN4
Summary
Part of SMN complex. Is expressed in several structures, including antennal anlage; antennal primordium; embryonic/larval midgut primordium; germline cell; and head epidermis primordium. Used to study neurodevelopmental disorder with microcephaly, cataracts, and renal abnormalities. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Glos in Genome Data Viewer
Location:
3F7-3F7; 1-5 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (3936517..3940582)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (3830550..3834615)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Gemin 4b Neighboring gene Gemin 4c

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Further delineation of GEMIN4 related neurodevelopmental disorder with microcephaly, cataract, and renal abnormalities syndrome. Altassan R, et al. Am J Med Genet A, 2022 Oct. PMID 35861185
  2. SMN complex member Gemin3 self-interacts and has a functional relationship with ALS-linked proteins TDP-43, FUS and Sod1. Cacciottolo R, et al. Sci Rep, 2019 Dec 10. PMID 31822699, Free PMC Article
  3. Intimate functional interactions between TGS1 and the Smn complex revealed by an analysis of the Drosophila eye development. Maccallini P, et al. PLoS Genet, 2020 May. PMID 32453722, Free PMC Article
  4. Disruption of Survival Motor Neuron in Glia Impacts Survival but has no Effect on Neuromuscular Function in Drosophila. Farrugia M, et al. Neuroscience, 2022 May 21. PMID 35314252
  5. Novel interactors of the Drosophila Survival Motor Neuron (SMN) Complex suggest its full conservation. Lanfranco M, et al. FEBS Lett, 2017 Nov. PMID 28949413

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 3940027-3940300 mobile_element_type = transposon:gypsy8{}1989

Gene Ontology Provided by FlyBase

Component Evidence Code Pubs
part_of SMN complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
gaulos
Names
CG2941-PA
CG2941-PB
Gemin4
Gemin4a
Glos-PA
Glos-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    3936517..3940582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001297919.1 → NP_001284848.1  gaulos, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284848.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W4N9

  2. NM_130730.2 → NP_570086.1  gaulos, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_570086.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W4N9
    Related
    FBpp0070586
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W4N9 Q9W4N9

Gene LinkOut

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