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Hook1 hook microtubule-tethering protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313370, updated on 4-Jan-2025

Summary

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Official Symbol
Hook1provided by RGD
Official Full Name
hook microtubule-tethering protein 1provided by RGD
Primary source
RGD:1309987
See related
EnsemblRapid:ENSRNOG00000026226 AllianceGenome:RGD:1309987
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cytoskeletal protein binding activity; dynein light intermediate chain binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including early endosome to late endosome transport; endosome to lysosome transport; and protein localization to perinuclear region of cytoplasm. Predicted to act upstream of or within Golgi organization and manchette assembly. Predicted to be located in microtubule cytoskeleton. Predicted to be part of FHF complex and HOPS complex. Predicted to be active in centrosome and cytoplasm. Orthologous to human HOOK1 (hook microtubule tethering protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Testes (RPKM 221.1), Kidney (RPKM 202.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hook1 in Genome Data Viewer
Location:
5q33
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (115940199..116003482)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (110824501..110887791)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (114940053..115000691)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene U1 spliceosomal RNA Neighboring gene FGGY carbohydrate kinase domain containing Neighboring gene uncharacterized LOC103692418 Neighboring gene uncharacterized LOC120102925 Neighboring gene cytochrome P450 2J3-like Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Dynein activator Hook1 is required for trafficking of BDNF-signaling endosomes in neurons. Olenick MA, et al. J Cell Biol, 2019 Jan 7. PMID 30373907, Free PMC Article
  2. The Hook1 gene is non-functional in the abnormal spermatozoon head shape (azh) mutant mouse. Mendoza-Lujambio I, et al. Hum Mol Genet, 2002 Jul 1. PMID 12075009
  3. Assembly of spermatid acrosome depends on microtubule organization during mammalian spermiogenesis. Moreno RD, et al. Dev Biol, 2006 May 1. PMID 16540102
  4. Interconnections of CLN3, Hook1 and Rab proteins link Batten disease to defects in the endocytic pathway. Luiro K, et al. Hum Mol Genet, 2004 Dec 1. PMID 15471887
  5. Spermatid perinuclear ribonucleic acid-binding protein binds microtubules in vitro and associates with abnormal manchettes in vivo in mice. Schumacher JM, et al. Biol Reprod, 1998 Jul. PMID 9674995

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cytoplasmic microtubule organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoskeleton-dependent intracellular transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome to lysosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in lysosome organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within manchette assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatid development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of FHF complex ISO
Inferred from Sequence Orthology
more info
  
part_of HOPS complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein Hook homolog 1
Names
hook homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107946.1 → NP_001101416.1  protein Hook homolog 1

    See identical proteins and their annotated locations for NP_001101416.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473998
    UniProtKB/TrEMBL
    A0A8I6AX65, A6JRI4, D3ZB48
    Related
    ENSRNOP00000012396.4, ENSRNOT00000012396.7
    Conserved Domains (2) summary
    pfam05622
    Location:15 → 720
    HOOK; HOOK protein
    cl19219
    Location:502 → 584
    DUF342; Protein of unknown function (DUF342)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    115940199..116003482
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287638.1 → XP_063143708.1  protein Hook homolog 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AX65
    Related
    ENSRNOP00000033736.2, ENSRNOT00000038196.3

  2. XM_039109897.2 → XP_038965825.1  protein Hook homolog 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AX65
    Related
    ENSRNOP00000102757.1, ENSRNOT00000162757.1
    Conserved Domains (2) summary
    pfam05622
    Location:191 → 724
    HOOK; HOOK protein
    cd22225
    Location:27 → 168
    HkD_Hook1; Hook domain found in protein Hook 1 (Hook1) and similar proteins

  3. XM_039109898.2 → XP_038965826.1  protein Hook homolog 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AX65

  4. XM_063287639.1 → XP_063143709.1  protein Hook homolog 1 isoform X4

RNA

  1. XR_005504438.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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