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DIP-alpha Dpr-interacting protein alpha [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31322, updated on 9-Dec-2024

Summary

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Official Symbol
DIP-alphaprovided by FlyBase
Official Full Name
Dpr-interacting protein alphaprovided by FlyBase
Primary source
FLYBASE:FBgn0052791
Locus tag
Dmel_CG32791
See related
AllianceGenome:FB:FBgn0052791
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
32791; CG13019; CG13020; CG32791; Dip-alpha; DIPalpha; Dmel\CG32791
Summary
Involved in synapse organization. Located in neuron projection membrane. Is expressed in ganglia; larval ventral midline glial cell; medulla; optic lobe intrinsic neurons; and ventral midline of embryo. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to several human genes including IGLON5 (IgLON family member 5); LSAMP (limbic system associated membrane protein); and NTM (neurotrimin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See DIP-alpha in Genome Data Viewer
Location:
3D4-3D6; 1-3 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (3507245..3571649, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (3401278..3465682, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44999 Neighboring gene uncharacterized protein Neighboring gene Growth arrest specific protein 8 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR34335 Neighboring gene pickpocket 8 Neighboring gene Allatostatin A receptor 1 Neighboring gene uncharacterized protein Neighboring gene Insulin-like peptide 7 Neighboring gene Poly(ADP-ribose) glycohydrolase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transsynaptic interactions between IgSF proteins DIP-α and Dpr10 are required for motor neuron targeting specificity. Ashley J, et al. Elife, 2019 Feb 4. PMID 30714906, Free PMC Article
  2. hkb is required for DIP-α expression and target recognition in the Drosophila neuromuscular circuit. Wang Y, et al. Commun Biol, 2024 Apr 27. PMID 38678127, Free PMC Article
  3. Synaptic Plasticity Induced by Differential Manipulation of Tonic and Phasic Motoneurons in Drosophila. Aponte-Santiago NA, et al. J Neurosci, 2020 Aug 12. PMID 32631939, Free PMC Article
  4. Glial Draper signaling triggers cross-neuron plasticity in bystander neurons after neuronal cell death in Drosophila. Wang Y, et al. Nat Commun, 2023 Jul 24. PMID 37488133, Free PMC Article
  5. Molecular basis of synaptic specificity by immunoglobulin superfamily receptors in Drosophila. Cheng S, et al. Elife, 2019 Jan 28. PMID 30688651, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. hkb is required for DIP-alpha expression and target recognition in the Drosophila neuromuscular circuit.
    Title: hkb is required for DIP-α expression and target recognition in the Drosophila neuromuscular circuit.
  2. We propose a model whereby DIP-alpha and Dpr10 on opposing synaptic partners interact with each other to generate proper motor neuron connectivity.
    Title: Transsynaptic interactions between IgSF proteins DIP-α and Dpr10 are required for motor neuron targeting specificity.
  3. different leg Motor neurons depend on the DIP-alpha and Dpr10 interaction to varying degrees that correlate with the morphological complexity of the Motor neurons and their muscle targets.
    Title: Stereotyped terminal axon branching of leg motor neurons mediated by IgSF proteins DIP-α and Dpr10.
  4. These studies support an important role for the DIP/Dpr protein interaction network in regulating cell-type-specific connectivity patterns.
    Title: Interactions between the Ig-Superfamily Proteins DIP-α and Dpr6/10 Regulate Assembly of Neural Circuits.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in synapse organization IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuron projection membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
Dpr-interacting protein alpha
Names
CG32791-PA
CG32791-PB
CG32791-PC
DIP-alpha-PA
DIP-alpha-PB
DIP-alpha-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    3507245..3571649 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272289.1 → NP_001259218.1  Dpr-interacting protein alpha, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259218.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W4R3
    Conserved Domains (4) summary
    smart00408
    Location:159 → 228
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:49 → 129
    IG_like; Immunoglobulin like
    pfam07679
    Location:144 → 240
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:244 → 337
    Ig; Immunoglobulin domain

  2. NM_001272288.2 → NP_001259217.1  Dpr-interacting protein alpha, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259217.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PGE1
    Conserved Domains (3) summary
    smart00408
    Location:37 → 106
    IGc2; Immunoglobulin C-2 Type
    pfam07679
    Location:22 → 118
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:122 → 215
    Ig; Immunoglobulin domain

  3. NM_166976.3 → NP_726871.1  Dpr-interacting protein alpha, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726871.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W4R3
    Related
    FBpp0070563
    Conserved Domains (4) summary
    smart00408
    Location:159 → 228
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:49 → 129
    IG_like; Immunoglobulin like
    pfam07679
    Location:144 → 240
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:244 → 337
    Ig; Immunoglobulin domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PGE1 M9PGE1
Q9W4R3 Q9W4R3

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