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Rbm12b RNA binding motif protein 12B [ Rattus norvegicus (Norway rat) ]

Gene ID: 313069, updated on 4-Jan-2025

Summary

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Official Symbol
Rbm12bprovided by RGD
Official Full Name
RNA binding motif protein 12Bprovided by RGD
Primary source
RGD:1307658
See related
EnsemblRapid:ENSRNOG00000016330 AllianceGenome:RGD:1307658
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307658
Summary
Predicted to enable RNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Orthologous to human RBM12B (RNA binding motif protein 12B). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 83.3), Thymus (RPKM 81.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rbm12b in Genome Data Viewer
Location:
5q13
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (30394756..30507428)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (25597405..25610324)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (25247990..25257678)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene RNA-binding protein 12B-A-like Neighboring gene transmembrane protein 67 Neighboring gene CBY1 interacting BAR domain containing 1 Neighboring gene uncharacterized LOC120102833 Neighboring gene triple QxxK/R motif containing Neighboring gene transfer RNA threonine (anticodon AGU) 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA-binding protein 12B
Names
RNA-binding protein 12B-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001408811.1 → NP_001395740.1  RNA-binding protein 12B

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A0G2JYP3, D3ZM54
    Related
    ENSRNOP00000058050.3, ENSRNOT00000061333.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    30394756..30507428
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110939.2 → XP_038966867.1  RNA-binding protein 12B isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYP3, D3ZM54
    Conserved Domains (5) summary
    PTZ00465
    Location:619 → 703
    PTZ00465; rhoptry-associated protein 1 (RAP-1); Provisional
    COG0724
    Location:367 → 581
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12746
    Location:152 → 237
    RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12748
    Location:401 → 476
    RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cl17169
    Location:2 → 80
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. XM_039110940.2 → XP_038966868.1  RNA-binding protein 12B isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYP3, D3ZM54
    Conserved Domains (5) summary
    PTZ00465
    Location:619 → 703
    PTZ00465; rhoptry-associated protein 1 (RAP-1); Provisional
    COG0724
    Location:367 → 581
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12746
    Location:152 → 237
    RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12748
    Location:401 → 476
    RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cl17169
    Location:2 → 80
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. XM_063287576.1 → XP_063143646.1  RNA-binding protein 12B isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYP3, D3ZM54

  4. XM_039110943.2 → XP_038966871.1  RNA-binding protein 12B isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYP3, D3ZM54
    Conserved Domains (5) summary
    PTZ00465
    Location:619 → 703
    PTZ00465; rhoptry-associated protein 1 (RAP-1); Provisional
    COG0724
    Location:367 → 581
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12746
    Location:152 → 237
    RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cd12748
    Location:401 → 476
    RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
    cl17169
    Location:2 → 80
    RRM_SF; RNA recognition motif (RRM) superfamily

  5. XM_063287578.1 → XP_063143648.1  RNA-binding protein 12B isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYP3, D3ZM54

  6. XM_063287577.1 → XP_063143647.1  RNA-binding protein 12B isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYP3, D3ZM54
Nucleotide Protein Strain
Heading Accession and Version

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