Zbtb8a zinc finger and BTB domain containing 8a [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zbtb8aprovided by RGD
Official Full Name: zinc finger and BTB domain containing 8aprovided by RGD
Primary source: RGD:1308756
See related: EnsemblRapid:ENSRNOG00000008300 AllianceGenome:RGD:1308756
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Zbtb8
Summary: Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription coactivator binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human ZBTB8A (zinc finger and BTB domain containing 8A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 25.8), Heart (RPKM 25.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (146977530..147005793, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (141693189..141721464, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (147554907..147584997, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AU048539 (e-PCR)
- UniSTS:144989

BM390930 (e-PCR)
- UniSTS:260964

RH137303 (e-PCR)
- UniSTS:219391

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator binding	IEA Inferred from Electronic Annotation more info
enables transcription coactivator binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger and BTB domain-containing protein 8A

Names: zinc finger and BTB domain containing 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107913.1 → NP_001101383.1 zinc finger and BTB domain-containing protein 8A isoform 2

See identical proteins and their annotated locations for NP_001101383.1

Status: PROVISIONAL

Source sequence(s)

CH473968

UniProtKB/TrEMBL

A0A8L2Q4Z4, A6ISI6

Conserved Domains (5) summary

smart00225
Location:2 → 72

BTB; Broad-Complex, Tramtrack and Bric a brac

COG5048
Location:232 → 285

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:234 → 254

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00651
Location:1 → 69

BTB; BTB/POZ domain

pfam13465
Location:246 → 271

zf-H2C2_2; Zinc-finger double domain
NM_001399150.1 → NP_001386079.1 zinc finger and BTB domain-containing protein 8A isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

B1WBU4

Related

ENSRNOP00000010983.6, ENSRNOT00000010983.7

Conserved Domains (4) summary

sd00017
Location:284 → 304

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18329
Location:3 → 118

BTB_POZ_ZBTB8A_BOZF1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A)

pfam13465
Location:296 → 321

zf-H2C2_2; Zinc-finger double domain

pfam13909
Location:282 → 306

zf-H2C2_5; C2H2-type zinc-finger domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

146977530..147005793 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109794.2 → XP_038965722.1 zinc finger and BTB domain-containing protein 8A isoform X1

UniProtKB/Swiss-Prot

B1WBU4

Conserved Domains (4) summary

sd00017
Location:284 → 304

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18329
Location:3 → 118

BTB_POZ_ZBTB8A_BOZF1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A)

pfam13465
Location:296 → 321

zf-H2C2_2; Zinc-finger double domain

pfam13909
Location:282 → 306

zf-H2C2_5; C2H2-type zinc-finger domain
XM_039109795.2 → XP_038965723.1 zinc finger and BTB domain-containing protein 8A isoform X2

Conserved Domains (1) summary

cd18329
Location:3 → 118

BTB_POZ_ZBTB8A_BOZF1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A)