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Eya3 EYA transcriptional coactivator and phosphatase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313027, updated on 4-Jan-2025

Summary

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Official Symbol
Eya3provided by RGD
Official Full Name
EYA transcriptional coactivator and phosphatase 3provided by RGD
Primary source
RGD:1309932
See related
EnsemblRapid:ENSRNOG00000010396 AllianceGenome:RGD:1309932
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable chromatin binding activity and phosphoprotein phosphatase activity. Predicted to be involved in several processes, including negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of DNA repair; and response to ionizing radiation. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in centrosome and nucleoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Orthologous to human EYA3 (EYA transcriptional coactivator and phosphatase 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 123.6), Thymus (RPKM 108.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Eya3 in Genome Data Viewer
Location:
5q36
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (150090535..150218855)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (144806523..144934522)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (150833754..150915390)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C8 Neighboring gene microRNA 3583 Neighboring gene platelet-activating factor receptor Neighboring gene uncharacterized LOC102548282 Neighboring gene U6 spliceosomal RNA Neighboring gene sphingomyelin phosphodiesterase, acid-like 3B Neighboring gene XK related 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Dephosphorylation of the C-terminal tyrosyl residue of the DNA damage-related histone H2A.X is mediated by the protein phosphatase eyes absent. Krishnan N, et al. J Biol Chem, 2009 Jun 12. PMID 19351884, Free PMC Article
  2. Eyes absent represents a class of protein tyrosine phosphatases. Rayapureddi JP, et al. Nature, 2003 Nov 20. PMID 14628052
  3. Ski regulates muscle terminal differentiation by transcriptional activation of Myog in a complex with Six1 and Eya3. Zhang H, et al. J Biol Chem, 2009 Jan 30. PMID 19008232, Free PMC Article
  4. Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya. Ohto H, et al. Mol Cell Biol, 1999 Oct. PMID 10490620, Free PMC Article
  5. Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. Cook PJ, et al. Nature, 2009 Apr 2. PMID 19234442, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables histone H2AXY142 phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine phosphatase activity, metal-dependent IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine/serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
eyes absent homolog 3
Names
eyes absent 3 homolog
NP_001101380.1
NP_001402793.1
NP_001402794.1
XP_006239087.1
XP_006239088.1
XP_006239089.1
XP_038965712.1
XP_038965714.1
XP_038965715.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107910.2 → NP_001101380.1  eyes absent homolog 3 isoform 3

    See identical proteins and their annotated locations for NP_001101380.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A6ISU4, D3ZHX6
    Related
    ENSRNOP00000109356.1, ENSRNOT00000167995.1
    Conserved Domains (1) summary
    TIGR01658
    Location:239 → 510
    EYA-cons_domain; eyes absent protein conserved domain

  2. NM_001415864.1 → NP_001402793.1  eyes absent homolog 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A0G2JZ01, A0A8I6AMN9
    Related
    ENSRNOP00000070857.2, ENSRNOT00000082945.3

  3. NM_001415865.1 → NP_001402794.1  eyes absent homolog 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    D3ZHX6
    Related
    ENSRNOP00000053016.4, ENSRNOT00000056170.4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    150090535..150218855
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109784.2 → XP_038965712.1  eyes absent homolog 3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JZ01
    Conserved Domains (2) summary
    TIGR01658
    Location:336 → 607
    EYA-cons_domain; eyes absent protein conserved domain
    pfam05109
    Location:164 → 304
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

  2. XM_039109786.2 → XP_038965714.1  eyes absent homolog 3 isoform X3

    UniProtKB/TrEMBL
    D3ZHX6
    Conserved Domains (2) summary
    TIGR01658
    Location:255 → 526
    EYA-cons_domain; eyes absent protein conserved domain
    cl41773
    Location:83 → 200
    SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

  3. XM_006239027.5 → XP_006239089.1  eyes absent homolog 3 isoform X3

    UniProtKB/TrEMBL
    D3ZHX6
    Related
    ENSRNOP00000109307.1, ENSRNOT00000148895.1
    Conserved Domains (2) summary
    TIGR01658
    Location:255 → 526
    EYA-cons_domain; eyes absent protein conserved domain
    cl41773
    Location:83 → 200
    SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

  4. XM_039109787.2 → XP_038965715.1  eyes absent homolog 3 isoform X4

    UniProtKB/TrEMBL
    A0A0G2JZ01
    Conserved Domains (2) summary
    TIGR01658
    Location:253 → 524
    EYA-cons_domain; eyes absent protein conserved domain
    pfam05109
    Location:81 → 221
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

  5. XM_006239025.5 → XP_006239087.1  eyes absent homolog 3 isoform X2

    See identical proteins and their annotated locations for XP_006239087.1

    UniProtKB/TrEMBL
    A0A0G2JZ01, A0A8I6AMN9
    Related
    ENSRNOP00000095246.1, ENSRNOT00000097388.2
    Conserved Domains (1) summary
    TIGR01658
    Location:301 → 572
    EYA-cons_domain; eyes absent protein conserved domain

  6. XM_006239026.4 → XP_006239088.1  eyes absent homolog 3 isoform X2

    See identical proteins and their annotated locations for XP_006239088.1

    UniProtKB/TrEMBL
    A0A0G2JZ01, A0A8I6AMN9
    Conserved Domains (1) summary
    TIGR01658
    Location:301 → 572
    EYA-cons_domain; eyes absent protein conserved domain
Nucleotide Protein Strain
Heading Accession and Version

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