Wasf2 WASP family member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Wasf2provided by RGD
Official Full Name: WASP family member 2provided by RGD
Primary source: RGD:1307299
See related: EnsemblRapid:ENSRNOG00000009805 AllianceGenome:RGD:1307299
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable Arp2/3 complex binding activity; SH3 domain binding activity; and protein kinase A regulatory subunit binding activity. Predicted to be involved in positive regulation of lamellipodium assembly; postsynaptic actin cytoskeleton organization; and regulation of actin filament organization. Predicted to act upstream of or within several processes, including Rac protein signal transduction; lamellipodium organization; and megakaryocyte development. Predicted to be located in cell-cell junction; early endosome; and ruffle. Predicted to be part of SCAR complex. Predicted to be active in lamellipodium and synapse. Orthologous to human WASF2 (WASP family member 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Thymus (RPKM 131.6), Spleen (RPKM 127.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (150620733..150685943)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (145336817..145402041)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (151319382..151385051)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dragon's Blood Regulates Rac1-WAVE2-Arp2/3 Signaling Pathway to Protect Rat Intestinal Epithelial Barrier Dysfunction Induced by Simulated Microgravity.
Title: Dragon's Blood Regulates Rac1-WAVE2-Arp2/3 Signaling Pathway to Protect Rat Intestinal Epithelial Barrier Dysfunction Induced by Simulated Microgravity.
The Arp2/3 regulators PICK1, and N-WASP and WAVE2 function antagonistically to control the complexity of astrocyte branched morphology, and this mechanism underlies the morphological changes seen in astrocytes during their response to pathological insult.
Title: The antagonistic modulation of Arp2/3 activity by N-WASP, WAVE2 and PICK1 defines dynamic changes in astrocyte morphology.
results indicate possible functions of dysbindin-1 at the postsynapse in the regulation of dendritic spine morphogenesis through the interaction with WAVE2 and Abi-1
Title: Dysbindin-1, WAVE2 and Abi-1 form a complex that regulates dendritic spine formation.
WAVE2 is essential for oligodendrocyte precursor cell migration regulated by platelet-derived growth factor PDGF.
Title: Cdk5 phosphorylation of WAVE2 regulates oligodendrocyte precursor cell migration through nonreceptor tyrosine kinase Fyn.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF400119 (e-PCR)
- UniSTS:244849

Wasf2 (e-PCR), detects polymorphism
- UniSTS:256993

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Arp2/3 complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables protein kinase A binding	ISO Inferred from Sequence Orthology more info
enables protein kinase A regulatory subunit binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Rac protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within actin filament-based movement	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ameboidal-type cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell motility	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lamellipodium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lamellipodium morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within megakaryocyte development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in postsynapse organization	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of SCAR complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SCAR complex	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in ruffle	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: actin-binding protein WASF2

Names: WAS protein family, member 2; wiskott-Aldrich syndrome protein family member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013167.2 → NP_001013185.1 actin-binding protein WASF2

See identical proteins and their annotated locations for NP_001013185.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A0G2K5T9, E9PTF9, Q5FWU0

Conserved Domains (2) summary

cd21762
Location:449 → 452

WH2; actin-binding sequence [structural motif]

cl41728
Location:427 → 478

WH2; Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif), and similar proteins
NM_001394051.1 → NP_001380980.1 actin-binding protein WASF2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A0G2K5T9, E9PTF9, Q5FWU0

Related

ENSRNOP00000063111.4, ENSRNOT00000067801.5

Conserved Domains (2) summary

cd21762
Location:449 → 452

WH2; actin-binding sequence [structural motif]

cl41728
Location:427 → 478

WH2; Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif), and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

150620733..150685943

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109782.2 → XP_038965710.1 actin-binding protein WASF2 isoform X1

UniProtKB/TrEMBL

A0A0G2K5T9, E9PTF9, Q5FWU0

Conserved Domains (2) summary

cd21762
Location:449 → 452

WH2; actin-binding sequence [structural motif]

cl41728
Location:427 → 478

WH2; Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif), and similar proteins
XM_039109783.2 → XP_038965711.1 actin-binding protein WASF2 isoform X1

UniProtKB/TrEMBL

A0A0G2K5T9, E9PTF9, Q5FWU0

Conserved Domains (2) summary

cd21762
Location:449 → 452

WH2; actin-binding sequence [structural motif]

cl41728
Location:427 → 478

WH2; Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif), and similar proteins
XM_039109781.2 → XP_038965709.1 actin-binding protein WASF2 isoform X1

UniProtKB/TrEMBL

A0A0G2K5T9, E9PTF9, Q5FWU0

Conserved Domains (2) summary

cd21762
Location:449 → 452

WH2; actin-binding sequence [structural motif]

cl41728
Location:427 → 478

WH2; Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif), and similar proteins