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Pianp PILR alpha associated neural protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 312711, updated on 4-Jan-2025

Summary

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Official Symbol
Pianpprovided by RGD
Official Full Name
PILR alpha associated neural proteinprovided by RGD
Primary source
RGD:1304952
See related
EnsemblRapid:ENSRNOG00000017052 AllianceGenome:RGD:1304952
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
PANP; leda-1; RGD1304952
Summary
Predicted to enable protein domain specific binding activity. Predicted to be involved in regulation of immune response. Predicted to act upstream of or within several processes, including brain development; glutamate secretion; and visual learning. Located in basolateral plasma membrane. Orthologous to human PIANP (PILR alpha associated neural protein). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 10.9), Adrenal (RPKM 10.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pianp in Genome Data Viewer
Location:
4q42
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (159482678..159491085)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (157796425..157804842)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (157508862..157517676)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene COP9 signalosome subunit 7A Neighboring gene uncharacterized LOC120102387 Neighboring gene zinc finger protein 384 Neighboring gene uncharacterized LOC102554095 Neighboring gene inhibitor of growth family, member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Liver sinusoidal endothelium: a microenvironment-dependent differentiation program in rat including the novel junctional protein liver endothelial differentiation-associated protein-1. Géraud C, et al. Hepatology, 2010 Jul. PMID 20578158
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cerebellum development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cerebellum development ISO
Inferred from Sequence Orthology
more info
  
involved_in dentate gyrus development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within dentate gyrus development ISO
Inferred from Sequence Orthology
more info
  
involved_in gamma-aminobutyric acid signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in gene expression IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in glutamate secretion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glutamate secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in homeostasis of number of cells IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within homeostasis of number of cells ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in response to stress IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to stress ISO
Inferred from Sequence Orthology
more info
  
involved_in social behavior IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within social behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in visual learning IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within visual learning ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
PILR alpha-associated neural protein
Names
PILR-associating neural protein
liver endothelial differentiation-associated protein-1
paired immunoglobin-like type 2 receptor-associating neural protein
uncharacterized protein C12orf53 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014059.1 → NP_001014081.1  PILR alpha-associated neural protein precursor

    See identical proteins and their annotated locations for NP_001014081.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085924
    UniProtKB/Swiss-Prot
    Q5U2P6
    UniProtKB/TrEMBL
    A6ILP0
    Related
    ENSRNOP00000060404.2, ENSRNOT00000065846.4
    Conserved Domains (1) summary
    pfam15298
    Location:191 → 232
    AJAP1_PANP_C; AJAP1/PANP C-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    159482678..159491085
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107681.2 → XP_038963609.1  PILR alpha-associated neural protein isoform X2

    UniProtKB/TrEMBL
    A0A8I6AV41, A6ILN7

  2. XM_039107680.2 → XP_038963608.1  PILR alpha-associated neural protein isoform X2

    UniProtKB/TrEMBL
    A0A8I6AV41, A6ILN7

  3. XM_008763286.4 → XP_008761508.1  PILR alpha-associated neural protein isoform X2

    See identical proteins and their annotated locations for XP_008761508.1

    UniProtKB/TrEMBL
    A0A8I6AV41, A6ILN7
    Related
    ENSRNOP00000097907.1, ENSRNOT00000099374.2
    Conserved Domains (1) summary
    pfam15298
    Location:191 → 232
    AJAP1_PANP_C; AJAP1/PANP C-terminus

  4. XM_017592652.3 → XP_017448141.1  PILR alpha-associated neural protein isoform X2

    UniProtKB/TrEMBL
    A0A8I6AV41, A6ILN7
    Conserved Domains (1) summary
    pfam15298
    Location:191 → 232
    AJAP1_PANP_C; AJAP1/PANP C-terminus

  5. XM_008763285.4 → XP_008761507.1  PILR alpha-associated neural protein isoform X1

    Conserved Domains (1) summary
    pfam15298
    Location:240 → 281
    AJAP1_PANP_C; AJAP1/PANP C-terminus

  6. XM_006237370.5 → XP_006237432.1  PILR alpha-associated neural protein isoform X2

    See identical proteins and their annotated locations for XP_006237432.1

    UniProtKB/TrEMBL
    A0A8I6AV41, A6ILN7
    Conserved Domains (1) summary
    pfam15298
    Location:191 → 232
    AJAP1_PANP_C; AJAP1/PANP C-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U2P6.1 GenPept UniProtKB/Swiss-Prot:Q5U2P6

Gene LinkOut

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