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Hdhd5 haloacid dehalogenase like hydrolase domain containing 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312680, updated on 9-Dec-2024

Summary

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Official Symbol
Hdhd5provided by RGD
Official Full Name
haloacid dehalogenase like hydrolase domain containing 5provided by RGD
Primary source
RGD:1306557
See related
EnsemblRapid:ENSRNOG00000011338 AllianceGenome:RGD:1306557
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cecr5
Summary
Predicted to be involved in glycerophospholipid biosynthetic process. Predicted to be active in mitochondrion. Orthologous to human HDHD5 (haloacid dehalogenase like hydrolase domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Adrenal (RPKM 131.7), Kidney (RPKM 66.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hdhd5 in Genome Data Viewer
Location:
4q42
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (155372781..155425496, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (153701026..153753303, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (153046701..153079065, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene interleukin 17 receptor A Neighboring gene transmembrane protein 121B Neighboring gene uncharacterized LOC108350753 Neighboring gene CECR2, histone acetyl-lysine reader

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
  2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in glycerophospholipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
haloacid dehalogenase-like hydrolase domain-containing 5
Names
cat eye syndrome chromosome region, candidate 5 homolog
cat eye syndrome critical region protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107884.1 → NP_001101354.1  haloacid dehalogenase-like hydrolase domain-containing 5

    See identical proteins and their annotated locations for NP_001101354.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473964
    UniProtKB/TrEMBL
    A0A8I6A520, A6ILA7
    Conserved Domains (2) summary
    TIGR01456
    Location:47 → 358
    CECR5; HAD-superfamily class IIA hydrolase, TIGR01456, CECR5
    pfam13344
    Location:49 → 152
    Hydrolase_6; Haloacid dehalogenase-like hydrolase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    155372781..155425496 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107661.2 → XP_038963589.1  haloacid dehalogenase-like hydrolase domain-containing 5 isoform X4

    Conserved Domains (1) summary
    TIGR01456
    Location:47 → 315
    CECR5; HAD-superfamily class IIA hydrolase, TIGR01456, CECR5

  2. XM_006237247.5 → XP_006237309.2  haloacid dehalogenase-like hydrolase domain-containing 5 isoform X2

    Conserved Domains (1) summary
    TIGR01456
    Location:47 → 315
    CECR5; HAD-superfamily class IIA hydrolase, TIGR01456, CECR5

  3. XM_063286119.1 → XP_063142189.1  haloacid dehalogenase-like hydrolase domain-containing 5 isoform X3

    UniProtKB/TrEMBL
    D3ZQB6
    Related
    ENSRNOP00000015090.7, ENSRNOT00000015090.7

  4. XM_006237246.5 → XP_006237308.2  haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A520
    Related
    ENSRNOP00000085914.1, ENSRNOT00000112876.2
Nucleotide Protein Strain
Heading Accession and Version

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