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fs(1)Yb female sterile (1) Yb [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31262, updated on 4-Jan-2025

Summary

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Official Symbol
fs(1)Ybprovided by FlyBase
Official Full Name
female sterile (1) Ybprovided by FlyBase
Primary source
FLYBASE:FBgn0000928
Locus tag
Dmel_CG2706
See related
AllianceGenome:FB:FBgn0000928
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2706; Dmel\CG2706; EG:95B7.8; fs(1)M104; Fs(1)Yb; fs(1)Y[b]; nov; yb; Yb; YB
Summary
Enables molecular condensate scaffold activity. Involved in germ cell development; germ-line stem cell population maintenance; and primary piRNA processing. Located in Yb body and cytosol. Is expressed in several structures, including ovarian sheath; ovariole; ovary; somatic cell of testis; and terminal filament. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See fs(1)Yb in Genome Data Viewer
Location:
3B3-3B3; 1-1.5 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2720468..2724158)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2614501..2618191)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene female sterile (1) Young arrest Neighboring gene vilya

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila maternal-effect gene fs(1)Ya encodes a cell cycle-dependent nuclear envelope component required for embryonic mitosis. Lin HF, et al. Cell, 1991 Jan 11. PMID 1986869
  2. Mutational analyses of fs(1)Ya, an essential, developmentally regulated, nuclear envelope protein in Drosophila. Liu J, et al. Genetics, 1995 Dec. PMID 8601487, Free PMC Article
  3. flam piRNA precursors channel from the nucleus to the cytoplasm in a temporally regulated manner along Drosophila oogenesis. Dennis C, et al. Mob DNA, 2019. PMID 31312260, Free PMC Article
  4. Yb integrates piRNA intermediates and processing factors into perinuclear bodies to enhance piRISC assembly. Murota Y, et al. Cell Rep, 2014 Jul 10. PMID 24953657
  5. Nonessential Sequences, Genes, and the Polytene Chromosome Bands of DROSOPHILA MELANOGASTER. Young MW, et al. Genetics, 1978 Apr. PMID 17248815, Free PMC Article

See all (106) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These findings shed light on distinct and collaborative requirements of Yb and Armi in transposon-targeting piRNA biogenesis.
    Title: Distinct and Collaborative Functions of Yb and Armitage in Transposon-Targeting piRNA Biogenesis.
  2. The Hel-C and eTud domains of Yb are crucial for Yb-Yb interactions and Yb binding with piRNA precursors.
    Title: Requirements for multivalent Yb body assembly in transposon silencing in Drosophila.
  3. We conclude that transcripts bound by Armi and Yb are identified as piRNA precursors, resulting in localization to cytoplasmic processing granules and their subsequent engagement by the resident piRNA biogenesis machinery.
    Title: Recruitment of Armitage and Yb to a transcript triggers its phased processing into primary piRNAs in Drosophila ovaries.
  4. Yb directly binds flam transcripts, but not neighboring protein-coding gene mRNAs.
    Title: Yb integrates piRNA intermediates and processing factors into perinuclear bodies to enhance piRISC assembly.
  5. Drosophila TUDOR domain-containing proteins interact with Vreteno and the Tdrd12 family, essential primary piRNA pathway factors
    Title: A systematic analysis of Drosophila TUDOR domain-containing proteins identifies Vreteno and the Tdrd12 family as essential primary piRNA pathway factors.
  6. roles for the cytoplasmic Yb body components Armitage and Yb in somatic primary piRNA biogenesis
    Title: Roles for the Yb body components Armitage and Yb in primary piRNA biogenesis in Drosophila.
  7. Yb protein is localized as discrete cytoplasmic spots exclusively in the somatic cells of the ovary and testis.
    Title: The Yb protein defines a novel organelle and regulates male germline stem cell self-renewal in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular condensate scaffold activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in germ cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ-line stem cell division IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in germ-line stem cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ-line stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in primary piRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Yb body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Yb body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
female sterile (1) Yb
Names
CG2706-PA
female sterile(1)M104
female sterile(1)Yb
fs(1)Yb-PA
no ovaries

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    2720468..2724158
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058146.4 → NP_477494.2  female sterile (1) Yb [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477494.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O76911, Q9W4W2
    Related
    FBpp0070462
    Conserved Domains (1) summary
    pfam00567
    Location:859 → 948
    TUDOR; Tudor domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MZ98 Q8MZ98
Q9UB20 Q9UB20
Q9W4W2 Q9W4W2

Gene LinkOut

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