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Prickle2 prickle planar cell polarity protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312563, updated on 27-Nov-2024

Summary

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Official Symbol
Prickle2provided by RGD
Official Full Name
prickle planar cell polarity protein 2provided by RGD
Primary source
RGD:1306723
See related
EnsemblRapid:ENSRNOG00000012364 AllianceGenome:RGD:1306723
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable zinc ion binding activity. Predicted to be involved in several processes, including embryonic brain development; maintenance of postsynaptic density structure; and regulation of postsynaptic density assembly. Predicted to act upstream of or within establishment or maintenance of epithelial cell apical/basal polarity and neuron projection development. Predicted to be located in apicolateral plasma membrane; cytoplasm; and lateral plasma membrane. Predicted to be active in glutamatergic synapse and postsynaptic density. Orthologous to human PRICKLE2 (prickle planar cell polarity protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 144.5), Brain (RPKM 120.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Prickle2 in Genome Data Viewer
Location:
4q34
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (126426767..126771986, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (124869655..125214862, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (124238167..124584176, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103692187 Neighboring gene uncharacterized LOC134486818 Neighboring gene rabenosyn, RAB effector Neighboring gene thyrotropin releasing hormone Neighboring gene uncharacterized LOC134486613 Neighboring gene uncharacterized LOC134486616 Neighboring gene uncharacterized LOC102554570 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif, 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. PDZ interaction of Vangl2 links PSD-95 and Prickle2 but plays only a limited role in the synaptic localisation of Vangl2. Nagaoka T, et al. Sci Rep, 2015 Aug 10. PMID 26257100, Free PMC Article
  2. Prickle promotes neurite outgrowth via the Dishevelled dependent pathway in C1300 cells. Fujimura L, et al. Neurosci Lett, 2009 Dec 18. PMID 19788910
  3. Planar cell polarity signaling in vertebrates. Jones C, et al. Bioessays, 2007 Feb. PMID 17226800, Free PMC Article
  4. Asymmetric distribution of prickle-like 2 reveals an early underlying polarization of vestibular sensory epithelia in the inner ear. Deans MR, et al. J Neurosci, 2007 Mar 21. PMID 17376975, Free PMC Article
  5. Nuclear localization of Prickle2 is required to establish cell polarity during early mouse embryogenesis. Tao H, et al. Dev Biol, 2012 Apr 15. PMID 22333836, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The PDZ interaction enhanced the protein interactions between PSD-95 and Prickle2, which is another planar cell polarity factor that is localised at the postsynaptic density.
    Title: PDZ interaction of Vangl2 links PSD-95 and Prickle2 but plays only a limited role in the synaptic localisation of Vangl2.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in embryonic brain development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within establishment or maintenance of epithelial cell apical/basal polarity ISO
Inferred from Sequence Orthology
more info
  
involved_in maintenance of postsynaptic density structure ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynaptic density assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in response to electrical stimulus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apicolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
prickle-like protein 2
Names
prickle homolog 2
prickle-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107876.3 → NP_001101346.1  prickle-like protein 2

    See identical proteins and their annotated locations for NP_001101346.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A6IBC5
    Conserved Domains (4) summary
    cd09415
    Location:130 → 188
    LIM1_Prickle; The first LIM domain of Prickle
    cd09418
    Location:193 → 248
    LIM2_Prickle; The second LIM domain of Prickle
    cd09420
    Location:253 → 311
    LIM3_Prickle; The third LIM domain of Prickle
    cd09827
    Location:26 → 122
    PET_Prickle; The PET domain of Prickle

  2. NM_001415880.2 → NP_001402809.1  prickle-like protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A6IBC5

  3. NM_001415881.2 → NP_001402810.1  prickle-like protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A6IBC5
    Related
    ENSRNOP00000104444.1, ENSRNOT00000155149.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    126426767..126771986 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107621.2 → XP_038963549.1  prickle-like protein 2 isoform X2

    Conserved Domains (4) summary
    cd09415
    Location:186 → 244
    LIM1_Prickle; The first LIM domain of Prickle
    cd09418
    Location:249 → 304
    LIM2_Prickle; The second LIM domain of Prickle
    cd09420
    Location:309 → 367
    LIM3_Prickle; The third LIM domain of Prickle
    cd09827
    Location:82 → 178
    PET_Prickle; The PET domain of Prickle

  2. XM_039107620.2 → XP_038963548.1  prickle-like protein 2 isoform X1

    UniProtKB/TrEMBL
    F1M0J7
    Related
    ENSRNOP00000016628.7, ENSRNOT00000016628.8
    Conserved Domains (4) summary
    cd09415
    Location:222 → 280
    LIM1_Prickle; The first LIM domain of Prickle
    cd09418
    Location:285 → 340
    LIM2_Prickle; The second LIM domain of Prickle
    cd09420
    Location:345 → 403
    LIM3_Prickle; The third LIM domain of Prickle
    cd09827
    Location:118 → 214
    PET_Prickle; The PET domain of Prickle

  3. XM_039107624.2 → XP_038963552.1  prickle-like protein 2 isoform X3

    Conserved Domains (4) summary
    cd09415
    Location:222 → 280
    LIM1_Prickle; The first LIM domain of Prickle
    cd09418
    Location:285 → 340
    LIM2_Prickle; The second LIM domain of Prickle
    cd09420
    Location:345 → 403
    LIM3_Prickle; The third LIM domain of Prickle
    cd09827
    Location:118 → 214
    PET_Prickle; The PET domain of Prickle
Nucleotide Protein Strain
Heading Accession and Version

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