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Lint-O L(3)mbt interactor in ovarian somatic cells [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31254, updated on 9-Dec-2024

Summary

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Official Symbol
Lint-Oprovided by FlyBase
Official Full Name
L(3)mbt interactor in ovarian somatic cellsprovided by FlyBase
Primary source
FLYBASE:FBgn0024993
Locus tag
Dmel_CG2662
See related
AllianceGenome:FB:FBgn0024993
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2662; Dmel\CG2662; EG:100G10.6; MAD; snuts
Summary
Enables chromatin binding activity. Involved in regulation of transcription by RNA polymerase II. Part of RNA polymerase II transcription regulator complex. Is active in nucleus. Is expressed in several structures, including antennal primordium; anterior endoderm; embryonic/larval midgut primordium; head epidermis primordium; and mesoderm. Orthologous to human SAMD1 (sterile alpha motif domain containing 1) and SAMD13 (sterile alpha motif domain containing 13). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Lint-O in Genome Data Viewer
Location:
3B2-3B2; 1-1.5 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2698701..2701033)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2592734..2595066)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene period Neighboring gene daywake Neighboring gene Paraplegin Neighboring gene UDP-galactose transporter Neighboring gene eukaryotic translation initiation factor 2B subunit beta Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Requirement for sex comb on midleg protein interactions in Drosophila polycomb group repression. Peterson AJ, et al. Genetics, 2004 Jul. PMID 15280237, Free PMC Article
  2. Lint-O cooperates with L(3)mbt in target gene suppression to maintain homeostasis in fly ovary and brain. Yamamoto-Matsuda H, et al. EMBO Rep, 2022 Oct 6. PMID 35993198, Free PMC Article
  3. Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD. Reddy BA, et al. Mol Cell Biol, 2010 Nov. PMID 20733004, Free PMC Article
  4. LTR-mediated retroposition as a mechanism of RNA-based duplication in metazoans. Tan S, et al. Genome Res, 2016 Dec. PMID 27934698, Free PMC Article
  5. Genome-wide analysis of retrogene polymorphisms in Drosophila melanogaster. Schrider DR, et al. Genome Res, 2011 Dec. PMID 22135405, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of PRC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase II transcription regulator complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
L(3)mbt interactor in ovarian somatic cells
Names
CG2662-PA
CG2662-PB
L(3)mbt interactor in OSCs
Lint-O-PA
Lint-O-PB
shrunken nuts

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    2698701..2701033
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001297903.1 → NP_001284832.1  L(3)mbt interactor in ovarian somatic cells, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284832.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O76866, Q9W4W7
    Conserved Domains (3) summary
    cd09583
    Location:371 → 438
    SAM_Atherin-like; SAM domain of Atherin/Atherin-like subfamily
    smart00454
    Location:371 → 436
    SAM; Sterile alpha motif
    smart00249
    Location:189 → 236
    PHD; PHD zinc finger

  2. NM_130662.3 → NP_570018.1  L(3)mbt interactor in ovarian somatic cells, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_570018.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O76866, Q9W4W7
    Related
    FBpp0070456
    Conserved Domains (3) summary
    cd09583
    Location:371 → 438
    SAM_Atherin-like; SAM domain of Atherin/Atherin-like subfamily
    smart00454
    Location:371 → 436
    SAM; Sterile alpha motif
    smart00249
    Location:189 → 236
    PHD; PHD zinc finger
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O76866 O76866
Q9W4W7 Q9W4W7

Gene LinkOut

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