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Gmcl1 germ cell-less 1, spermatogenesis associated [ Rattus norvegicus (Norway rat) ]

Gene ID: 312516, updated on 27-Nov-2024

Summary

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Official Symbol
Gmcl1provided by RGD
Official Full Name
germ cell-less 1, spermatogenesis associatedprovided by RGD
Primary source
RGD:1359265
See related
EnsemblRapid:ENSRNOG00000017838 AllianceGenome:RGD:1359265
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gcl
Summary
This gene encodes a nuclear envelope protein that contains a broad-complex, tramtrack and bric a brac/ Pox virus and Zinc finger (BTB/POZ) protein-protein interaction domain. In mouse, this gene is expressed at high levels in the testis, and null mutant mice exhibit morphologically abnormal sperm that have chromatin condensation defects. These defects result in significantly impaired fertility, demonstrating a role for this gene in male germ cell development in mouse. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
Expression
Biased expression in Testes (RPKM 129.8), Thymus (RPKM 96.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gmcl1 in Genome Data Viewer
Location:
4q34
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (120697976..120737267, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (119140598..119179891, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (118494997..118534301, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene max dimerization protein 1 Neighboring gene uncharacterized LOC134486607 Neighboring gene small nuclear ribonucleoprotein U4/U6.U5 subunit 27 Neighboring gene annexin A4 Neighboring gene small nucleolar RNA SNORA2/SNORA34 family Neighboring gene uncharacterized LOC134486606

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Stage-specific expression of mouse germ cell-less-1 (mGCL-1), and multiple deformations during mgcl-1 deficient spermatogenesis leading to reduced fertility. Maekawa M, et al. Arch Histol Cytol, 2004 Nov. PMID 15700541
  2. Reduced human germ cell-less (HGCL) expression in azoospermic men with severe germinal cell impairment. Kleiman SE, et al. J Androl, 2003 Sep-Oct. PMID 12954656
  3. Mouse germ cell-less as an essential component for nuclear integrity. Kimura T, et al. Mol Cell Biol, 2003 Feb. PMID 12556490, Free PMC Article
  4. Enhanced degradation of MDM2 by a nuclear envelope component, mouse germ cell-less. Masuhara M, et al. Biochem Biophys Res Commun, 2003 Sep 5. PMID 12927808
  5. Identification of a mouse germ cell-less homologue with conserved activity in Drosophila. Leatherman JL, et al. Mech Dev, 2000 Apr. PMID 10727854

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in germ cell development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
germ cell-less protein-like 1
Names
germ cell-less homolog 1
germ cell-less, spermatogenesis associated 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010956.3 → NP_001010956.1  germ cell-less protein-like 1 isoform 2

    See identical proteins and their annotated locations for NP_001010956.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks the 3'-terminal exon and has a 3' end that extends into an intron compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BP492225, FM064983, JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A0G2K533, Q5I286
    Conserved Domains (3) summary
    smart00225
    Location:107 → 206
    BTB; Broad-Complex, Tramtrack and Bric a brac
    smart00875
    Location:211 → 281
    BACK; BTB And C-terminal Kelch
    pfam00651
    Location:96 → 203
    BTB; BTB/POZ domain

  2. NM_001033931.2 → NP_001029103.1  germ cell-less protein-like 1 isoform 1

    See identical proteins and their annotated locations for NP_001029103.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BP492225, FM064983, JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A0G2K533, A6IAZ0, F7ERJ6, Q5I287
    Related
    ENSRNOP00000024414.5, ENSRNOT00000024414.7
    Conserved Domains (2) summary
    cd18305
    Location:91 → 205
    BTB_POZ_GCL; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins
    cd18495
    Location:206 → 283
    BACK_GCL; BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    120697976..120737267 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236832.5 → XP_006236894.1  germ cell-less protein-like 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K533, A0A8I6B2P7
    Related
    ENSRNOP00000095491.1, ENSRNOT00000118148.2
    Conserved Domains (2) summary
    smart00225
    Location:107 → 206
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00651
    Location:96 → 203
    BTB; BTB/POZ domain

RNA

  1. XR_010065645.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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