U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rab11fip5 RAB11 family interacting protein 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312502, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Rab11fip5provided by RGD
Official Full Name
RAB11 family interacting protein 5provided by RGD
Primary source
RGD:1592069
See related
EnsemblRapid:ENSRNOG00000056009 AllianceGenome:RGD:1592069
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable gamma-tubulin binding activity. Predicted to be involved in several processes, including postsynaptic neurotransmitter receptor internalization; regulation of protein localization; and secretion by cell. Predicted to act upstream of or within cellular response to type II interferon. Predicted to be located in several cellular components, including centriolar satellite; cytoplasmic vesicle; and mitochondrial outer membrane. Orthologous to human RAB11FIP5 (RAB11 family interacting protein 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 148.8), Heart (RPKM 133.8) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Rab11fip5 in Genome Data Viewer
Location:
4q34
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (119428766..119466277, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (117871301..117908819, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (117113067..117154495, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102324 Neighboring gene empty spiracles homeobox 1 Neighboring gene sideroflexin 5 Neighboring gene argininosuccinate synthase 1, pseudogene 2 Neighboring gene notochord homeobox

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The rab11 effector protein FIP1 regulates adiponectin trafficking and secretion. Carson BP, et al. PLoS One, 2013. PMID 24040321, Free PMC Article
  2. Rab11b and its effector Rip11 regulate the acidosis-induced traffic of V-ATPase in salivary ducts. Oehlke O, et al. J Cell Physiol, 2011 Mar. PMID 20717956
  3. Rab11 and its effector Rip11 participate in regulation of insulin granule exocytosis. Sugawara K, et al. Genes Cells, 2009 Apr. PMID 19335615
  4. Gaf-1, a gamma -SNAP-binding protein associated with the mitochondria. Chen D, et al. J Biol Chem, 2001 Apr 20. PMID 11278501
  5. The phagosomal proteome in interferon-gamma-activated macrophages. Trost M, et al. Immunity, 2009 Jan 16. PMID 19144319

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables gamma-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to acidic pH ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to type II interferon ISO
Inferred from Sequence Orthology
more info
  
involved_in insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of adiponectin secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in postsynaptic neurotransmitter receptor internalization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulated exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulated exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in phagocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
rab11 family-interacting protein 5
Names
RAB11 family interacting protein 5 (class I)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399548.1 → NP_001386477.1  rab11 family-interacting protein 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A0G2K4A0
    Related
    ENSRNOP00000072961.2, ENSRNOT00000091374.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    119428766..119466277 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108722.2 → XP_038964650.1  rab11 family-interacting protein 5 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K1W1
    Related
    ENSRNOP00000072006.2, ENSRNOT00000086720.3
    Conserved Domains (2) summary
    pfam09457
    Location:1265 → 1311
    RBD-FIP; FIP domain
    cl14603
    Location:21 → 167
    C2; C2 domain

  2. XM_039108723.2 → XP_038964651.1  rab11 family-interacting protein 5 isoform X2

    Conserved Domains (2) summary
    pfam09457
    Location:1163 → 1209
    RBD-FIP; FIP domain
    cl14603
    Location:21 → 167
    C2; C2 domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools