HLH3B - Helix loop helix protein 3B
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in several structures, including embryonic brain; larval ventral midline neurons; midline primordium; and ventral midline of embryo. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia; acute lymphoblastic leukemia; and adult T-cell leukemia/lymphoma. Orthologous to several human genes including TAL2 (TAL bHLH transcription factor 2). [provided by Alliance of Genome Resources, Dec 2024]
NCBI Orthologs
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Protein alignment
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