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Mindy4 MINDY lysine 48 deubiquitinase 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312365, updated on 4-Jan-2025

Summary

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Official Symbol
Mindy4provided by RGD
Official Full Name
MINDY lysine 48 deubiquitinase 4provided by RGD
Primary source
RGD:1562590
See related
EnsemblRapid:ENSRNOG00000011530 AllianceGenome:RGD:1562590
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fam188b; RGD1562590
Summary
Predicted to enable K48-linked deubiquitinase activity. Predicted to be involved in protein K48-linked deubiquitination and proteolysis. Orthologous to human MINDY4 (MINDY lysine 48 deubiquitinase 4). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Lung (RPKM 37.9), Kidney (RPKM 33.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mindy4 in Genome Data Viewer
Location:
4q24
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (85689049..85797553)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (84358660..84469189)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (85427741..85536264)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550746 Neighboring gene indolethylamine N-methyltransferase Neighboring gene aquaporin 1 Neighboring gene growth hormone releasing hormone receptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables K48-linked deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein K48-linked deubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
MINDY lysine 48 deubiquitinase 4; probable ubiquitin carboxyl-terminal hydrolase MINDY-4
Names
family with sequence similarity 188, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001431721.1 → NP_001418650.1  MINDY lysine 48 deubiquitinase 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    D3ZJJ0

RNA

  1. NR_197244.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    85689049..85797553
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_231787.10 → XP_231787.5  probable ubiquitin carboxyl-terminal hydrolase MINDY-4 isoform X2

    Related
    ENSRNOP00000015469.7, ENSRNOT00000015469.10
    Conserved Domains (1) summary
    pfam13898
    Location:415 → 751
    DUF4205; Domain of unknown function (DUF4205)

  2. XM_039108680.2 → XP_038964608.1  probable ubiquitin carboxyl-terminal hydrolase MINDY-4 isoform X1

    Conserved Domains (1) summary
    pfam13898
    Location:483 → 819
    DUF4205; Domain of unknown function (DUF4205)

  3. XM_063286962.1 → XP_063143032.1  probable ubiquitin carboxyl-terminal hydrolase MINDY-4 isoform X4

  4. XM_039108681.2 → XP_038964609.1  probable ubiquitin carboxyl-terminal hydrolase MINDY-4 isoform X3

    Conserved Domains (1) summary
    pfam13898
    Location:85 → 421
    DUF4205; Domain of unknown function (DUF4205)

RNA

  1. XR_005503604.2 RNA Sequence

  2. XR_005503605.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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