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Zfp746 zinc finger protein 746 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312303, updated on 4-Jan-2025

Summary

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Official Symbol
Zfp746provided by RGD
Official Full Name
zinc finger protein 746provided by RGD
Primary source
RGD:1306209
See related
EnsemblRapid:ENSRNOG00000007064 AllianceGenome:RGD:1306209
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Znf746; RGD1306209
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in protein complex oligomerization and regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Orthologous to several human genes including ZNF746 (zinc finger protein 746). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 79.8), Spleen (RPKM 53.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zfp746 in Genome Data Viewer
Location:
4q24
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (78385945..78410240, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (77055008..77078968, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (77723182..77747511, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene transfer RNA cysteine (anticodon GCA) 1 Neighboring gene zinc finger protein 777 Neighboring gene transfer RNA cysteine (anticodon GCA) 2 Neighboring gene transfer RNA cysteine (anticodon GCA) 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease. Shin JH, et al. Cell, 2011 Mar 4. PMID 21376232, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein heterooligomerization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 746

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100852.1 → NP_001094322.1  zinc finger protein 746

    See identical proteins and their annotated locations for NP_001094322.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I6AAQ7, F1LSG4
    Related
    ENSRNOP00000009247.4, ENSRNOT00000009247.7
    Conserved Domains (6) summary
    smart00349
    Location:107 → 156
    KRAB; krueppel associated box
    COG5048
    Location:516 → 594
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:517 → 537
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:571 → 593
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:25 → 81
    DUF3669; Zinc finger protein
    pfam13465
    Location:558 → 582
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    78385945..78410240 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107551.2 → XP_038963479.1  zinc finger protein 746 isoform X8

    UniProtKB/TrEMBL
    A0A8I6AAQ7
    Conserved Domains (6) summary
    smart00349
    Location:107 → 156
    KRAB; krueppel associated box
    COG5048
    Location:473 → 551
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:474 → 494
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:528 → 550
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:25 → 81
    DUF3669; Zinc finger protein
    pfam13465
    Location:515 → 539
    zf-H2C2_2; Zinc-finger double domain

  2. XM_063286027.1 → XP_063142097.1  zinc finger protein 746 isoform X7

    UniProtKB/TrEMBL
    A0A8I5YBV9, A0A8I6AAQ7
    Related
    ENSRNOP00000076748.1, ENSRNOT00000114087.2

  3. XM_006236419.5 → XP_006236481.1  zinc finger protein 746 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AAQ7
    Conserved Domains (6) summary
    smart00349
    Location:107 → 156
    KRAB; krueppel associated box
    COG5048
    Location:515 → 593
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:516 → 536
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:570 → 592
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:25 → 81
    DUF3669; Zinc finger protein
    pfam13465
    Location:557 → 581
    zf-H2C2_2; Zinc-finger double domain

  4. XM_039107550.2 → XP_038963478.1  zinc finger protein 746 isoform X6

    UniProtKB/TrEMBL
    A0A8I6AAQ7
    Conserved Domains (6) summary
    smart00349
    Location:113 → 162
    KRAB; krueppel associated box
    COG5048
    Location:479 → 557
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:480 → 500
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:534 → 556
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:31 → 87
    DUF3669; Zinc finger protein
    pfam13465
    Location:521 → 545
    zf-H2C2_2; Zinc-finger double domain

  5. XM_039107549.2 → XP_038963477.1  zinc finger protein 746 isoform X5

    UniProtKB/TrEMBL
    A0A8I6AAQ7
    Conserved Domains (6) summary
    smart00349
    Location:113 → 162
    KRAB; krueppel associated box
    COG5048
    Location:480 → 558
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:481 → 501
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:535 → 557
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:31 → 87
    DUF3669; Zinc finger protein
    pfam13465
    Location:522 → 546
    zf-H2C2_2; Zinc-finger double domain

  6. XM_039107548.2 → XP_038963476.1  zinc finger protein 746 isoform X4

    UniProtKB/TrEMBL
    A0A8I6AAQ7
    Conserved Domains (6) summary
    COG5048
    Location:484 → 562
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:485 → 505
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:539 → 561
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:31 → 87
    DUF3669; Zinc finger protein
    pfam13465
    Location:526 → 550
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:113 → 163
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  7. XM_039107547.2 → XP_038963475.1  zinc finger protein 746 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AAQ7
    Conserved Domains (6) summary
    smart00349
    Location:113 → 162
    KRAB; krueppel associated box
    COG5048
    Location:521 → 599
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:522 → 542
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:576 → 598
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:31 → 87
    DUF3669; Zinc finger protein
    pfam13465
    Location:563 → 587
    zf-H2C2_2; Zinc-finger double domain

  8. XM_008762887.4 → XP_008761109.1  zinc finger protein 746 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AAQ7
    Related
    ENSRNOP00000088391.2, ENSRNOT00000108359.2
    Conserved Domains (6) summary
    cd07765
    Location:114 → 141
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:113 → 162
    KRAB; krueppel associated box
    COG5048
    Location:522 → 600
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:523 → 543
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:577 → 599
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:535 → 559
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

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