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Dennd2a DENN domain containing 2A [ Rattus norvegicus (Norway rat) ]

Gene ID: 312257, updated on 27-Nov-2024

Summary

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Official Symbol
Dennd2aprovided by RGD
Official Full Name
DENN domain containing 2Aprovided by RGD
Primary source
RGD:1306142
See related
EnsemblRapid:ENSRNOG00000026748 AllianceGenome:RGD:1306142
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1306142
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in retrograde transport, endosome to Golgi. Predicted to be located in cytosol. Predicted to be active in actin cytoskeleton. Orthologous to human DENND2A (DENN domain containing 2A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 63.7), Liver (RPKM 42.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dennd2a in Genome Data Viewer
Location:
4q23
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (69199814..69299128, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (68233016..68332235, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (67242257..67342993, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene RAB19, member RAS oncogene family Neighboring gene makorin ring finger protein 1 Neighboring gene small nucleolar RNA SNORA71 Neighboring gene serine and arginine rich splicing factor 3, pseudogene 6 Neighboring gene aarF domain containing kinase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. Yoshimura S, et al. J Cell Biol, 2010 Oct 18. PMID 20937701, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DENN domain-containing protein 2A
Names
DENN/MADD domain containing 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427610.1 → NP_001414539.1  DENN domain-containing protein 2A

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    D3ZLQ1
    Related
    ENSRNOP00000034734.3, ENSRNOT00000034549.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    69199814..69299128 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286009.1 → XP_063142079.1  DENN domain-containing protein 2A isoform X2

  2. XM_006236354.4 → XP_006236416.1  DENN domain-containing protein 2A isoform X1

    See identical proteins and their annotated locations for XP_006236416.1

    UniProtKB/TrEMBL
    A0A8I6AL22, D3ZLQ1
    Conserved Domains (3) summary
    smart00801
    Location:893 → 951
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:552 → 644
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:651 → 807
    DENN; DENN (AEX-3) domain

  3. XM_039109022.2 → XP_038964950.1  DENN domain-containing protein 2A isoform X2

    UniProtKB/TrEMBL
    A0A8I6AL22
    Conserved Domains (3) summary
    smart00801
    Location:892 → 950
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:551 → 643
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:650 → 806
    DENN; DENN (AEX-3) domain

  4. XM_039109021.2 → XP_038964949.1  DENN domain-containing protein 2A isoform X1

    UniProtKB/TrEMBL
    A0A8I6AL22, D3ZLQ1
    Conserved Domains (3) summary
    smart00801
    Location:893 → 951
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:552 → 644
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:651 → 807
    DENN; DENN (AEX-3) domain

  5. XM_008762851.3 → XP_008761073.1  DENN domain-containing protein 2A isoform X1

    See identical proteins and their annotated locations for XP_008761073.1

    UniProtKB/TrEMBL
    A0A8I6AL22, D3ZLQ1
    Conserved Domains (3) summary
    smart00801
    Location:893 → 951
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:552 → 644
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:651 → 807
    DENN; DENN (AEX-3) domain

  6. XM_063286008.1 → XP_063142078.1  DENN domain-containing protein 2A isoform X1

    UniProtKB/TrEMBL
    D3ZLQ1
Nucleotide Protein Strain
Heading Accession and Version

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