Slc23a4 solute carrier family 23 member 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc23a4provided by RGD
Official Full Name: solute carrier family 23 member 4provided by RGD
Primary source: RGD:1565367
See related: EnsemblRapid:ENSRNOG00000026919 AllianceGenome:RGD:1565367
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SNBT1; RGD1565367
Summary: Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Thymus (RPKM 97.3), Lung (RPKM 15.2) and 1 other tissue See more
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Genomic context

Location:: 4q22

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (64598429..64646168, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (63631292..63679687, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (62480058..62526724, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study shows that urate uptake was observed only barely in the everted tissue sacs of the rat small intestine, in which sodium-dependent nucleobase transporter 1 operates for nucleobase uptake. Findings suggested that urate undergoes a futile cycle, in which urate transported into epithelial cells is immediately effluxed back by urate efflux transporters, in the small intestine.
Title: Urate transport function of rat sodium-dependent nucleobase transporter 1.
identification of rat Slc23a4 as the first sodium-dependent nucleobase transporter (rSNBT1). The mRNA of rSNBT1 was expressed highly and only in the small intestine
Title: Identification and functional characterization of the first nucleobase transporter in mammals: implication in the species difference in the intestinal absorption mechanism of nucleobases and their analogs between higher primates and other mammals.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: solute carrier family 23 member 2-like

Names: sodium-dependent nucleobase transporter 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270038.2 → NP_001256967.1 solute carrier family 23 member 2-like

See identical proteins and their annotated locations for NP_001256967.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A0A8I6GLA0, D2KX48, D4A4K8

Related

ENSRNOP00000030381.5, ENSRNOT00000038950.7

Conserved Domains (2) summary

pfam00860
Location:57 → 487

Xan_ur_permease; Permease family

cl23746
Location:49 → 530

HCO3_cotransp; HCO3- transporter family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

64598429..64646168 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063285989.1 → XP_063142059.1 solute carrier family 23 member 2-like isoform X1
XM_039107520.2 → XP_038963448.1 solute carrier family 23 member 2-like isoform X2

Conserved Domains (1) summary

cl23746
Location:93 → 310

Xan_ur_permease; Permease family