Ilp6 Insulin-like peptide 6 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ilp6provided by FlyBase
Official Full Name: Insulin-like peptide 6provided by FlyBase
Primary source: FLYBASE:FBgn0044047
Locus tag: Dmel_CG14049
See related: AllianceGenome:FB:FBgn0044047
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: aIGF; aIGF-short; CG14049; dilp; Dilp; DILP; Dilp 6; DILP 6; dilp-6; dILP-6; DILP-6; dilp6; dIlp6; dILP6; Dilp6; DIlP6; DILP6; DILPs; dlp; Dmel\CG14049; Ilp; Ilp-6; ilp6; ILP6; ILPs; llp6
Summary: Predicted to enable insulin receptor binding activity. Involved in cellular response to starvation; insulin receptor signaling pathway; and regulation of growth. Predicted to be located in extracellular space. Is expressed in adult fat body; embryonic/larval midgut; fat body; larval ventral nerve cord; and organism. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 3A1-3A1; 1-1 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (2331493..2334658, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (2225526..2228691, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Independent insulin signaling modulators govern hot avoidance under different feeding states.
Title: Independent insulin signaling modulators govern hot avoidance under different feeding states.
it was demonstrated for the first time that insulin-like DILP6 protein in drosophila influences the level of octopamine (regulating the activity of the enzyme degrading octopamine).
Title: [Gene dilp6 regulates octopamine metabolism in Drosophila melanogaster].
suggest a feedback system in the interaction between juvenile hormone and DILP6 in which DILP6 negatively regulates the JH titre via an increase in the hormone degradation and a decrease in its synthesis
Title: Insulin-like peptide DILP6 regulates juvenile hormone and dopamine metabolism in Drosophila females.
Fat body-derived Drosophila insulin-like peptide 6 induces lipid uptake in oenocytes, promoting lipid turnover during fasting and increasing starvation tolerance.
Title: Control of metabolic adaptation to fasting by dILP6-induced insulin signaling in Drosophila oenocytes.
Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain.
Title: Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain.
Shows that Drosophila insulin-like peptide 6 (DILP6), which is structurally similar to vertebrate insulin-like growth factor (IGF), is predominantly expressed in the fat body, a functional equivalent of the vertebrate liver and adipocytes.
Title: A fat body-derived IGF-like peptide regulates postfeeding growth in Drosophila.
Study shows that during metamorphosis, when feeding stops, a specific DILP (Dilp6) is produced by the fat body and relays the growth signal; expression of DILP6 during pupal development is controlled by the steroid hormone ecdysone.
Title: A Drosophila insulin-like peptide promotes growth during nonfeeding states.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables insulin receptor binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: Insulin-like peptide 6

Names: CG14049-PA; CG14049-PB; CG14049-PC; CG14049-PD; Ilp6-PA; Ilp6-PB; Ilp6-PC; Ilp6-PD; drosophila insulin-like peptide 6; insulin-like peptide; insulin-like peptide 6

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

2331493..2334658 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_130644.4 → NP_570000.1 Insulin-like peptide 6, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_570000.1

Status: REVIEWED

UniProtKB/Swiss-Prot

C4XVH4, Q9W4Z4

UniProtKB/TrEMBL

E7BBS5, T2HXA7

Related

FBpp0070390

Conserved Domains (1) summary

cl02453
Location:78 → 105

IlGF_like; Insulin/insulin-like growth factor/relaxin family; insulin family of proteins. Members include a number of active peptides which are evolutionary related including insulin, relaxin, prorelaxin, insulin-like growth factors I and II, mammalian Leydig ...
NM_001201610.2 → NP_001188539.1 Insulin-like peptide 6, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188539.1

Status: REVIEWED

UniProtKB/Swiss-Prot

C4XVH4, Q9W4Z4

UniProtKB/TrEMBL

E7BBS5, T2HXA7

Conserved Domains (1) summary

cl02453
Location:78 → 105

IlGF_like; Insulin/insulin-like growth factor/relaxin family; insulin family of proteins. Members include a number of active peptides which are evolutionary related including insulin, relaxin, prorelaxin, insulin-like growth factors I and II, mammalian Leydig ...
NM_001201609.1 → NP_001188538.1 Insulin-like peptide 6, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188538.1

Status: REVIEWED

UniProtKB/Swiss-Prot

C4XVH4, Q9W4Z4

UniProtKB/TrEMBL

E7BBS5, T2HXA7

Conserved Domains (1) summary

cl02453
Location:78 → 105

IlGF_like; Insulin/insulin-like growth factor/relaxin family; insulin family of proteins. Members include a number of active peptides which are evolutionary related including insulin, relaxin, prorelaxin, insulin-like growth factors I and II, mammalian Leydig ...
NM_001272256.1 → NP_001259185.1 Insulin-like peptide 6, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259185.1

Status: REVIEWED

UniProtKB/Swiss-Prot

C4XVH4, Q9W4Z4

UniProtKB/TrEMBL

E7BBS5, T2HXA7

Conserved Domains (1) summary

cl02453
Location:78 → 105

IlGF_like; Insulin/insulin-like growth factor/relaxin family; insulin family of proteins. Members include a number of active peptides which are evolutionary related including insulin, relaxin, prorelaxin, insulin-like growth factors I and II, mammalian Leydig ...