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Grp170 Grp170 co-chaperone [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31215, updated on 9-Dec-2024

Summary

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Official Symbol
Grp170provided by FlyBase
Official Full Name
Grp170 co-chaperoneprovided by FlyBase
Primary source
FLYBASE:FBgn0023529
Locus tag
Dmel_CG2918
See related
AllianceGenome:FB:FBgn0023529
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2918; CT9894; Dmel\CG2918; EG:25E8.1; GRP170
Summary
Predicted to enable adenyl-nucleotide exchange factor activity and unfolded protein binding activity. Predicted to be involved in cellular response to hypoxia. Located in extracellular space. Is expressed in several structures, including adult head; adult heart; anterior endoderm anlage; dorsal ectoderm; and gut section. Human ortholog(s) of this gene implicated in immunodeficiency 59. Orthologous to human HYOU1 (hypoxia up-regulated 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Grp170 in Genome Data Viewer
Location:
2F3-2F4; 1-0.9 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2271008..2275068, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2165041..2169101, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45480 Neighboring gene Vitelline membrane-like Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The hsp110 and Grp1 70 stress proteins: newly recognized relatives of the Hsp70s. Easton DP, et al. Cell Stress Chaperones, 2000 Oct. PMID 11048651, Free PMC Article
  2. Enrichment of O-GlcNAc modified proteins by the periodate oxidation-hydrazide resin capture approach. Klement E, et al. J Proteome Res, 2010 May 7. PMID 20146544, Free PMC Article
  3. ATM/Chk2 and ATR/Chk1 Pathways Respond to DNA Damage Induced by Movento(®) 240SC and Envidor(®) 240SC Keto-Enol Insecticides in the Germarium of Drosophila melanogaster. González-Marín B, et al. Toxics, 2023 Sep 6. PMID 37755764, Free PMC Article
  4. The Drosophila ETV5 Homologue Ets96B: Molecular Link between Obesity and Bipolar Disorder. Williams MJ, et al. PLoS Genet, 2016 Jun. PMID 27280443, Free PMC Article
  5. Proteomic identification of Drosophila melanogaster male accessory gland proteins, including a pro-cathepsin and a soluble gamma-glutamyl transpeptidase. Walker MJ, et al. Proteome Sci, 2006 May 2. PMID 16670001, Free PMC Article

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables adenyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cellular response to hypoxia ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endomembrane system HDA PubMed 
part_of endoplasmic reticulum chaperone complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum lumen ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Grp170 co-chaperone
Names
CG2918-PA
CG2918-PB
Grp170-PA
Grp170-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    2271008..2275068 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001169174.2 → NP_001162645.1  Grp170 co-chaperone, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162645.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O46067
    Conserved Domains (3) summary
    cd10230
    Location:23 → 409
    HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
    pfam00012
    Location:22 → 625
    HSP70; Hsp70 protein
    cl05005
    Location:572 → 627
    TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

  2. NM_130639.4 → NP_569995.1  Grp170 co-chaperone, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_569995.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O46067
    Related
    FBpp0070395
    Conserved Domains (3) summary
    cd10230
    Location:23 → 409
    HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins
    pfam00012
    Location:22 → 625
    HSP70; Hsp70 protein
    cl05005
    Location:572 → 627
    TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O46067 O46067

Gene LinkOut

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