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CG2924 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31214, updated on 4-Jan-2025

Summary

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Official Symbol
CG2924provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0023528
Locus tag
Dmel_CG2924
See related
AllianceGenome:FB:FBgn0023528
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG2924; EG:25E8.2; NICE5
Summary
Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein K48-linked ubiquitination. Predicted to be active in nucleus. Is expressed in organism. Orthologous to several human genes including UBE2Q1 (ubiquitin conjugating enzyme E2 Q1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See CG2924 in Genome Data Viewer
Location:
2F2-2F3; 1-0.9 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2264657..2270761, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2158690..2164794, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tempura Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45480 Neighboring gene Grp170 co-chaperone Neighboring gene Vitelline membrane-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of novel genes that modify phenotypes induced by Alzheimer's beta-amyloid overexpression in Drosophila. Cao W, et al. Genetics, 2008 Mar. PMID 18245849, Free PMC Article
  2. A survey of ovary-, testis-, and soma-biased gene expression in Drosophila melanogaster adults. Parisi M, et al. Genome Biol, 2004. PMID 15186491, Free PMC Article
  3. Identification of downstream targets of the bone morphogenetic protein pathway in the Drosophila nervous system. Kim NC, et al. Dev Dyn, 2010 Sep. PMID 20652954
  4. Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin-conjugating enzymes, ubiquitin-activating enzymes, and ubiquitin-like proteins. Jones D, et al. Genome Biol, 2002. PMID 11806825, Free PMC Article
  5. What was the set of ubiquitin and ubiquitin-like conjugating enzymes in the eukaryote common ancestor? Michelle C, et al. J Mol Evol, 2009 Jun. PMID 19452197, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein K48-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG2924-PA
CG2924-PB
CG2924-PD
CG2924-PE
NP_001284819.1
NP_001284820.1
NP_569994.1
NP_726805.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    2264657..2270761 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001297890.1 → NP_001284819.1  uncharacterized protein Dmel_CG2924, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284819.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q29R09, Q86M59
    Conserved Domains (1) summary
    cd00195
    Location:224 → 349
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  2. NM_166935.3 → NP_726805.1  uncharacterized protein Dmel_CG2924, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726805.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q29R09, Q86M59
    Related
    FBpp0070396
    Conserved Domains (1) summary
    cd00195
    Location:224 → 349
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  3. NM_130638.4 → NP_569994.1  uncharacterized protein Dmel_CG2924, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_569994.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q29R09, Q86M59
    Related
    FBpp0290017
    Conserved Domains (1) summary
    cd00195
    Location:224 → 349
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  4. NM_001297891.1 → NP_001284820.1  uncharacterized protein Dmel_CG2924, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284820.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q29R09, Q86M59
    Conserved Domains (1) summary
    cd00195
    Location:224 → 349
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O46068 O46068
Q29R09 Q29R09
Q86M59 Q86M59
Q8T3U4 Q8T3U4

Gene LinkOut

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