Gsap gamma-secretase activating protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gsapprovided by RGD
Official Full Name: gamma-secretase activating proteinprovided by RGD
Primary source: RGD:1563271
See related: EnsemblRapid:ENSRNOG00000028801 AllianceGenome:RGD:1563271
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pion
Summary: Predicted to enable amyloid-beta binding activity. Predicted to be involved in positive regulation of amyloid-beta formation and regulation of proteolysis. Predicted to be active in trans-Golgi network. Orthologous to human GSAP (gamma-secretase activating protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 130.5), Lung (RPKM 106.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q11

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (14705237..14800057, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (13813046..13907875, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (10423090..10517887, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

gamma-secretase activating protein (GSAP) and imatinib have roles in the regulation of gamma-secretase activity and amyloid-beta generation
Title: The role of γ-secretase activating protein (GSAP) and imatinib in the regulation of γ-secretase activity and amyloid-β generation.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of amyloid-beta formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of amyloid-beta formation	ISO Inferred from Sequence Orthology more info
involved_in regulation of proteolysis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: gamma-secretase-activating protein

Names: pigeon homolog; protein pigeon homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395028.2 → NP_001381957.1 gamma-secretase-activating protein

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A0A0G2JWZ3, A0A8I6A0P7, A6K5C2

Related

ENSRNOP00000070072.1, ENSRNOT00000083964.3

Conserved Domains (1) summary

pfam14959
Location:634 → 741

GSAP-16; gamma-Secretase-activating protein C-term

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

14705237..14800057 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008762649.4 → XP_008760871.1 gamma-secretase-activating protein isoform X1

UniProtKB/TrEMBL

A0A8I6A0P7

Conserved Domains (1) summary

pfam14959
Location:634 → 741

GSAP-16; gamma-Secretase-activating protein C-term
XM_063285956.1 → XP_063142026.1 gamma-secretase-activating protein isoform X2
XM_039107498.2 → XP_038963426.1 gamma-secretase-activating protein isoform X3

RNA

XR_005503210.2 RNA Sequence
XR_005503209.2 RNA Sequence
XR_010065635.1 RNA Sequence
XR_010065636.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001107845.1: Suppressed sequence

Description

NM_001107845.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.