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Dennd1a DENN domain containing 1A [ Rattus norvegicus (Norway rat) ]

Gene ID: 311913, updated on 27-Nov-2024

Summary

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Official Symbol
Dennd1aprovided by RGD
Official Full Name
DENN domain containing 1Aprovided by RGD
Primary source
RGD:1307927
See related
EnsemblRapid:ENSRNOG00000010526 AllianceGenome:RGD:1307927
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307927
Summary
Predicted to enable several functions, including SH3 domain binding activity; guanyl-nucleotide exchange factor activity; and phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in several processes, including endocytic recycling; positive regulation of GTPase activity; and regulation of Rab protein signal transduction. Predicted to act upstream of or within synaptic vesicle endocytosis. Predicted to be located in several cellular components, including clathrin-coated vesicle membrane; dendrite; and neuronal cell body. Predicted to be active in clathrin-coated vesicle and cytosol. Orthologous to human DENND1A (DENN domain containing 1A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 59.6), Spleen (RPKM 45.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dennd1a in Genome Data Viewer
Location:
3q11-q12
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (41974502..42461816, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (21564749..22052057, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (22061120..22501502, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene crumbs cell polarity complex component 2 Neighboring gene LIM homeobox 2 Neighboring gene uncharacterized LOC120101538 Neighboring gene double PHD fingers 3 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The Connecdenn DENN domain: a GEF for Rab35 mediating cargo-specific exit from early endosomes. Allaire PD, et al. Mol Cell, 2010 Feb 12. PMID 20159556, Free PMC Article
  2. Connecdenn, a novel DENN domain-containing protein of neuronal clathrin-coated vesicles functioning in synaptic vesicle endocytosis. Allaire PD, et al. J Neurosci, 2006 Dec 20. PMID 17182770, Free PMC Article
  3. The NECAP PHear domain increases clathrin accessory protein binding potential. Ritter B, et al. EMBO J, 2007 Sep 19. PMID 17762867, Free PMC Article
  4. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. Yoshimura S, et al. J Cell Biol, 2010 Oct 18. PMID 20937701, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytic recycling ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Rab protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in clathrin-coated vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in clathrin-coated vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in clathrin-coated vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  
located_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DENN domain-containing protein 1A
Names
DENN/MADD domain containing 1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191747.1 → NP_001178676.1  DENN domain-containing protein 1A isoform a

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6GKQ9
    Related
    ENSRNOP00000025443.6, ENSRNOT00000025443.6
    Conserved Domains (3) summary
    smart00801
    Location:306 → 372
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:96 → 274
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:10 → 92
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  2. NM_001434229.1 → NP_001421158.1  DENN domain-containing protein 1A isoform b

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    41974502..42461816 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039105292.2 → XP_038961220.1  DENN domain-containing protein 1A isoform X14

    UniProtKB/TrEMBL
    A0A8I6GKQ9
    Related
    ENSRNOP00000094401.2, ENSRNOT00000116730.2
    Conserved Domains (4) summary
    smart00801
    Location:357 → 423
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:147 → 325
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:61 → 143
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    PHA03247
    Location:696 → 1030
    PHA03247; large tegument protein UL36; Provisional

  2. XM_039105287.2 → XP_038961215.1  DENN domain-containing protein 1A isoform X8

    UniProtKB/TrEMBL
    A0A8I5ZKB0
    Related
    ENSRNOP00000105651.1, ENSRNOT00000145932.1
    Conserved Domains (4) summary
    smart00801
    Location:357 → 423
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:147 → 325
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:61 → 143
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    PHA03247
    Location:739 → 1073
    PHA03247; large tegument protein UL36; Provisional

  3. XM_039105285.2 → XP_038961213.1  DENN domain-containing protein 1A isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZKB0
    Conserved Domains (4) summary
    smart00801
    Location:357 → 423
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:147 → 325
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:61 → 143
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    PHA03247
    Location:758 → 1092
    PHA03247; large tegument protein UL36; Provisional

  4. XM_063283988.1 → XP_063140058.1  DENN domain-containing protein 1A isoform X17

    UniProtKB/TrEMBL
    A0A8I6A7I2
    Related
    ENSRNOP00000088926.2, ENSRNOT00000096396.2

  5. XM_063283984.1 → XP_063140054.1  DENN domain-containing protein 1A isoform X12

    Related
    ENSRNOP00000102796.1, ENSRNOT00000169280.1

  6. XM_039105281.2 → XP_038961209.1  DENN domain-containing protein 1A isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZKB0
    Conserved Domains (4) summary
    smart00801
    Location:387 → 475
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:177 → 355
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:61 → 173
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    PHA03247
    Location:810 → 1144
    PHA03247; large tegument protein UL36; Provisional

  7. XM_063283977.1 → XP_063140047.1  DENN domain-containing protein 1A isoform X2

  8. XM_063283985.1 → XP_063140055.1  DENN domain-containing protein 1A isoform X13

    Related
    ENSRNOP00000077456.2, ENSRNOT00000097346.2

  9. XM_063283986.1 → XP_063140056.1  DENN domain-containing protein 1A isoform X15

  10. XM_039105289.2 → XP_038961217.1  DENN domain-containing protein 1A isoform X10

    UniProtKB/TrEMBL
    A0A8I5ZKB0
    Conserved Domains (4) summary
    smart00801
    Location:307 → 395
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:97 → 275
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:46 → 93
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    PHA03247
    Location:730 → 1064
    PHA03247; large tegument protein UL36; Provisional

  11. XM_063283980.1 → XP_063140050.1  DENN domain-containing protein 1A isoform X6

  12. XM_039105290.2 → XP_038961218.1  DENN domain-containing protein 1A isoform X11

    UniProtKB/TrEMBL
    A0A8I5ZKB0
    Conserved Domains (4) summary
    smart00801
    Location:305 → 393
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:95 → 273
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:9 → 91
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    PHA03247
    Location:728 → 1062
    PHA03247; large tegument protein UL36; Provisional

  13. XM_063283987.1 → XP_063140057.1  DENN domain-containing protein 1A isoform X16

  14. XM_063283989.1 → XP_063140059.1  DENN domain-containing protein 1A isoform X18

    UniProtKB/TrEMBL
    F1M241
    Related
    ENSRNOP00000078866.1, ENSRNOT00000108920.2

  15. XM_063283990.1 → XP_063140060.1  DENN domain-containing protein 1A isoform X19

  16. XM_063283981.1 → XP_063140051.1  DENN domain-containing protein 1A isoform X7

  17. XM_063283978.1 → XP_063140048.1  DENN domain-containing protein 1A isoform X3

  18. XM_063283979.1 → XP_063140049.1  DENN domain-containing protein 1A isoform X5

  19. XM_063283982.1 → XP_063140052.1  DENN domain-containing protein 1A isoform X9

  20. XM_063283991.1 → XP_063140061.1  DENN domain-containing protein 1A isoform X19

  21. XM_063283992.1 → XP_063140062.1  DENN domain-containing protein 1A isoform X20

  22. XM_063283993.1 → XP_063140063.1  DENN domain-containing protein 1A isoform X21

  23. XM_063283995.1 → XP_063140065.1  DENN domain-containing protein 1A isoform X23

  24. XM_063283998.1 → XP_063140068.1  DENN domain-containing protein 1A isoform X26

  25. XM_063283994.1 → XP_063140064.1  DENN domain-containing protein 1A isoform X22

  26. XM_063283996.1 → XP_063140066.1  DENN domain-containing protein 1A isoform X24

  27. XM_063283997.1 → XP_063140067.1  DENN domain-containing protein 1A isoform X25

Nucleotide Protein Strain
Heading Accession and Version

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