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Agpat2 1-acylglycerol-3-phosphate O-acyltransferase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311821, updated on 27-Nov-2024

Summary

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Official Symbol
Agpat2provided by RGD
Official Full Name
1-acylglycerol-3-phosphate O-acyltransferase 2provided by RGD
Primary source
RGD:1309229
See related
EnsemblRapid:ENSRNOG00000019466 AllianceGenome:RGD:1309229
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity. Involved in epidermis development and response to xenobiotic stimulus. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital generalized lipodystrophy type 1 and lipodystrophy. Orthologous to human AGPAT2 (1-acylglycerol-3-phosphate O-acyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 894.1), Thymus (RPKM 467.7) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Agpat2 in Genome Data Viewer
Location:
3p13
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (29814924..29826569, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (9416837..9428567, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (4044741..4055384, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 198 Neighboring gene EGF-like-domain, multiple 7 Neighboring gene microRNA 126a Neighboring gene microRNA 126b Neighboring gene divergent protein kinase domain 1B Neighboring gene uncharacterized LOC100911266 Neighboring gene small nucleolar RNA SNORA43

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Proteomic analysis of rat hippocampus exposed to the antidepressant paroxetine. McHugh PC, et al. J Psychopharmacol, 2010 Aug. PMID 19346281
  2. Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy. Cortés VA, et al. Cell Metab, 2009 Feb. PMID 19187773, Free PMC Article
  3. Enzymatic activity of naturally occurring 1-acylglycerol-3-phosphate-O-acyltransferase 2 mutants associated with congenital generalized lipodystrophy. Haque W, et al. Biochem Biophys Res Commun, 2005 Feb 11. PMID 15629135
  4. Human lysophosphatidic acid acyltransferase. cDNA cloning, expression, and localization to chromosome 9q34.3. Eberhardt C, et al. J Biol Chem, 1997 Aug 8. PMID 9242711
  5. AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34. Agarwal AK, et al. Nat Genet, 2002 May. PMID 11967537

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in epidermis development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in phosphatidic acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
  
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
1-acyl-sn-glycerol-3-phosphate acyltransferase beta
Names
1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)
NP_001101291.1
XP_038961130.1
XP_038961131.1
XP_038961133.1
XP_038961134.1
XP_038961135.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107821.3 → NP_001101291.1  1-acyl-sn-glycerol-3-phosphate acyltransferase beta

    See identical proteins and their annotated locations for NP_001101291.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6JTG5
    Conserved Domains (1) summary
    cd07989
    Location:67 → 240
    LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    29814924..29826569 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039105202.2 → XP_038961130.1  1-acyl-sn-glycerol-3-phosphate acyltransferase beta isoform X1

    UniProtKB/TrEMBL
    D4AC45
    Related
    ENSRNOP00000026408.5, ENSRNOT00000026408.9
    Conserved Domains (1) summary
    cd07989
    Location:54 → 227
    LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

  2. XM_039105207.2 → XP_038961135.1  1-acyl-sn-glycerol-3-phosphate acyltransferase beta isoform X2

    Conserved Domains (1) summary
    cd07989
    Location:4 → 137
    LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

  3. XM_039105203.2 → XP_038961131.1  1-acyl-sn-glycerol-3-phosphate acyltransferase beta isoform X2

    Conserved Domains (1) summary
    cd07989
    Location:4 → 137
    LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

  4. XM_039105205.2 → XP_038961133.1  1-acyl-sn-glycerol-3-phosphate acyltransferase beta isoform X2

    Conserved Domains (1) summary
    cd07989
    Location:4 → 137
    LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

  5. XM_039105206.2 → XP_038961134.1  1-acyl-sn-glycerol-3-phosphate acyltransferase beta isoform X2

    Conserved Domains (1) summary
    cd07989
    Location:4 → 137
    LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
Nucleotide Protein Strain
Heading Accession and Version

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