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ph-p - polyhomeotic proximal

Enables several functions, including DNA topoisomerase binding activity; chromatin binding activity; and protein-folding chaperone binding activity. Involved in several processes, including follicle cell of egg chamber development; regulation of gene expression; and syncytial blastoderm mitotic cell cycle. Located in nucleolus and polytene chromosome. Part of PRC1 complex. Is expressed in several structures, including epithelium; germline cell; imaginal disc; presumptive embryonic/larval system; and synaptic neuropil subdomain. Used to study cancer. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 11. Orthologous to several human genes including PHC1 (polyhomeotic homolog 1) and PHC3 (polyhomeotic homolog 3). [provided by Alliance of Genome Resources, Nov 2024]

Genes similar to ph-p

NCBI Orthologs

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Species Gene Architecture aa