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Metap1d methionyl aminopeptidase type 1D (mitochondrial) [ Rattus norvegicus (Norway rat) ]

Gene ID: 311748, updated on 4-Jan-2025

Summary

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Official Symbol
Metap1dprovided by RGD
Official Full Name
methionyl aminopeptidase type 1D (mitochondrial)provided by RGD
Primary source
RGD:1307413
See related
EnsemblRapid:ENSRNOG00000061587 AllianceGenome:RGD:1307413
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Map1d; Metapl1
Summary
Predicted to enable metalloaminopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in mitochondrion. Orthologous to human METAP1D (methionyl aminopeptidase type 1D, mitochondrial). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 29.1), Adrenal (RPKM 25.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Metap1d in Genome Data Viewer
Location:
3q23
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (76687149..76759681)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (56279471..56354518)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (58084558..58160748)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene histone acetyltransferase 1 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC102549016 Neighboring gene uncharacterized LOC108350393 Neighboring gene distal-less homeobox 1 Neighboring gene distal-less homeobox 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. An unusual peptide deformylase features in the human mitochondrial N-terminal methionine excision pathway. Serero A, et al. J Biol Chem, 2003 Dec 26. PMID 14532271
  2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables initiator methionyl aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloaminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
methionine aminopeptidase 1D, mitochondrial
Names
methionine aminopeptidase-like 1
NP_001101282.2
XP_038961094.1
XP_038961096.1
XP_038961097.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107812.2 → NP_001101282.2  methionine aminopeptidase 1D, mitochondrial

    See identical proteins and their annotated locations for NP_001101282.2

    Status: VALIDATED

    Source sequence(s)
    BC167092, DY575699
    UniProtKB/TrEMBL
    A6HM49, B2RZB4, G3V670
    Related
    ENSRNOP00000072048.1, ENSRNOT00000084797.3
    Conserved Domains (1) summary
    cd01086
    Location:93 → 329
    MetAP1; Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    76687149..76759681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039105166.2 → XP_038961094.1  methionine aminopeptidase 1D, mitochondrial isoform X1

    UniProtKB/TrEMBL
    B2RZB4
    Conserved Domains (1) summary
    cd01086
    Location:65 → 279
    MetAP1; Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.

  2. XM_039105169.2 → XP_038961097.1  methionine aminopeptidase 1D, mitochondrial isoform X3

    UniProtKB/TrEMBL
    A6HM50
    Conserved Domains (1) summary
    PLN03158
    Location:54 → 179
    PLN03158; methionine aminopeptidase; Provisional

  3. XM_039105168.2 → XP_038961096.1  methionine aminopeptidase 1D, mitochondrial isoform X2

    Conserved Domains (1) summary
    cd01086
    Location:1 → 212
    MetAP1; Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.

RNA

  1. XR_005501905.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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