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Myh7b myosin heavy chain 7B [ Rattus norvegicus (Norway rat) ]

Gene ID: 311570, updated on 9-Dec-2024

Summary

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Official Symbol
Myh7bprovided by RGD
Official Full Name
myosin heavy chain 7Bprovided by RGD
Primary source
RGD:1307994
See related
EnsemblRapid:ENSRNOG00000018997 AllianceGenome:RGD:1307994
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable actin filament binding activity and microfilament motor activity. Involved in regulation of CAMKK-AMPK signaling cascade; regulation of cardiac muscle cell contraction; and regulation of cytosolic calcium ion concentration. Predicted to be located in cardiac myofibril. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Used to study hypertrophic cardiomyopathy. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to human MYH7B (myosin heavy chain 7B). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Heart (RPKM 126.2), Kidney (RPKM 60.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Myh7b in Genome Data Viewer
Location:
3q42
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (164537211..164582441)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (144076911..144122714)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (151105038..151150621)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene gamma-glutamyltransferase 7 Neighboring gene small nucleolar RNA SNORA18 Neighboring gene acyl-CoA synthetase short-chain family member 2 Neighboring gene glutathione synthetase Neighboring gene microRNA 499a Neighboring gene transient receptor potential cation channel, subfamily C, member 4 associated protein Neighboring gene ER degradation enhancing alpha-mannosidase like protein 2 Neighboring gene protein C receptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Regulation of synapse structure and function by distinct myosin II motors. Rubio MD, et al. J Neurosci, 2011 Jan 26. PMID 21273429, Free PMC Article
  2. The role of MAP-kinase p38 in the m. soleus slow myosin mRNA transcription regulation during short-term functional unloading. Sharlo KA, et al. Arch Biochem Biophys, 2020 Nov 30. PMID 33053365
  3. Developmental expression and cardiac transcriptional regulation of Myh7b, a third myosin heavy chain in the vertebrate heart. Warkman AS, et al. Cytoskeleton (Hoboken), 2012 May. PMID 22422726, Free PMC Article
  4. MYH7B variants cause hypertrophic cardiomyopathy by activating the CaMK-signaling pathway. Chen P, et al. Sci China Life Sci, 2020 Sep. PMID 32207065
  5. l-Arginine Attenuates Cardiac Dysfunction, But Further Down-Regulates α-Myosin Heavy Chain Expression in Isoproterenol-Induced Cardiomyopathy. Kralova E, et al. Basic Clin Pharmacol Toxicol, 2015 Oct. PMID 25865156

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The role of MAP-kinase p38 in the m. soleus slow myosin mRNA transcription regulation during short-term functional unloading.
    Title: The role of MAP-kinase p38 in the m. soleus slow myosin mRNA transcription regulation during short-term functional unloading.
  2. Myosin II motor activity is emerging as a broad regulatory mechanism for control over complex actin networks within dendritic spines.
    Title: Regulation of synapse structure and function by distinct myosin II motors.
  3. Myh7b, the ortholog of slow myosin 2 (SM2) of frogs and birds, is detected as mRNA in heart, slow muscles and extraocular muscles. MYH7b protein is detected only in a minor fiber population in extraocular muscles, corresponding to slow-tonic fibers.
    Title: Two novel/ancient myosins in mammalian skeletal muscles: MYH14/7b and MYH15 are expressed in extraocular muscles and muscle spindles.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of CAMKK-AMPK signaling cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of calcium-mediated signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cardiac muscle cell contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cardiac myofibril ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in myosin filament IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
myosin-7B
Names
myosin, heavy chain 7B, cardiac muscle, beta
myosin, heavy polypeptide 7B, cardiac muscle, beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107794.2 → NP_001101264.2  myosin-7B

    See identical proteins and their annotated locations for NP_001101264.2

    Status: PROVISIONAL

    Source sequence(s)
    EU241478
    UniProtKB/TrEMBL
    B6RK61
    Related
    ENSRNOP00000106404.1, ENSRNOT00000148538.1
    Conserved Domains (3) summary
    cd14927
    Location:98 → 773
    MYSc_Myh7b; class II myosin heavy chain 7b, motor domain
    pfam01576
    Location:853 → 1930
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:32 → 71
    Myosin_N; Myosin N-terminal SH3-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    164537211..164582441
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039105078.2 → XP_038961006.1  myosin-7B isoform X1

    UniProtKB/TrEMBL
    B6RK61
    Conserved Domains (3) summary
    cd14927
    Location:98 → 773
    MYSc_Myh7b; class II myosin heavy chain 7b, motor domain
    pfam01576
    Location:853 → 1930
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:32 → 71
    Myosin_N; Myosin N-terminal SH3-like domain

  2. XM_039105079.2 → XP_038961007.1  myosin-7B isoform X2

    Conserved Domains (3) summary
    cd14927
    Location:98 → 773
    MYSc_Myh7b; class II myosin heavy chain 7b, motor domain
    pfam01576
    Location:853 → 1930
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:32 → 71
    Myosin_N; Myosin N-terminal SH3-like domain

  3. XM_017591783.3 → XP_017447272.1  myosin-7B isoform X1

    UniProtKB/TrEMBL
    B6RK61
    Conserved Domains (3) summary
    cd14927
    Location:98 → 773
    MYSc_Myh7b; class II myosin heavy chain 7b, motor domain
    pfam01576
    Location:853 → 1930
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:32 → 71
    Myosin_N; Myosin N-terminal SH3-like domain

  4. XM_039105080.2 → XP_038961008.1  myosin-7B isoform X3

    Conserved Domains (2) summary
    pfam01576
    Location:624 → 1701
    Myosin_tail_1; Myosin tail
    cl22853
    Location:1 → 544
    Motor_domain; Myosin and Kinesin motor domain
Nucleotide Protein Strain
Heading Accession and Version

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