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Nanp N-acetylneuraminic acid phosphatase [ Rattus norvegicus (Norway rat) ]

Gene ID: 311530, updated on 27-Nov-2024

Summary

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Official Symbol
Nanpprovided by RGD
Official Full Name
N-acetylneuraminic acid phosphataseprovided by RGD
Primary source
RGD:1306009
See related
EnsemblRapid:ENSRNOG00000074422 AllianceGenome:RGD:1306009
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hdhd4; RGD1306009
Summary
Enables N-acylneuraminate-9-phosphatase activity. Involved in N-acetylneuraminate biosynthetic process. Is active in cytosol. Orthologous to human NANP (N-acetylneuraminic acid phosphatase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 49.5), Thymus (RPKM 37.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nanp in Genome Data Viewer
Location:
3q41
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (160289269..160302001, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (139826549..139841655, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (146800018..146812988, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 722 Neighboring gene ninein-like Neighboring gene uncharacterized LOC134486182 Neighboring gene uncharacterized LOC134486183 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Subcellular localization and tissue distribution of sialic acid-forming enzymes. N-acetylneuraminate-9-phosphate synthase and N-acetylneuraminate 9-phosphatase. Van Rinsum J, et al. Biochem J, 1984 Oct 15. PMID 6093772, Free PMC Article
  2. Identification of the sequence encoding N-acetylneuraminate-9-phosphate phosphatase. Maliekal P, et al. Glycobiology, 2006 Feb. PMID 16237198
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC105812

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables N-acylneuraminate-9-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acylneuraminate-9-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N-acylneuraminate-9-phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in CMP-N-acetylneuraminate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in N-acetylglucosamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in N-acetylneuraminate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in N-acetylneuraminate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in N-acetylneuraminate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycosylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
N-acylneuraminate-9-phosphatase
Names
haloacid dehalogenase-like hydrolase domain containing 4
neu5Ac-9-Pase
NP_001009409.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009409.1 → NP_001009409.1  N-acylneuraminate-9-phosphatase

    Status: REVIEWED

    Source sequence(s)
    BC087587, CO399358, CO568277
    UniProtKB/Swiss-Prot
    Q5M969
    UniProtKB/TrEMBL
    A6KHH8
    Related
    ENSRNOP00000106707.1, ENSRNOT00000173334.1
    Conserved Domains (1) summary
    TIGR02253
    Location:6 → 234
    CTE7; HAD superfamily (subfamily IA) hydrolase, TIGR02253

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    160289269..160302001 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5M969.1 GenPept UniProtKB/Swiss-Prot:Q5M969

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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