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Pgam5 Phosphoglycerate mutase 5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31143, updated on 9-Dec-2024

Summary

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Official Symbol
Pgam5provided by FlyBase
Official Full Name
Phosphoglycerate mutase 5provided by FlyBase
Primary source
FLYBASE:FBgn0023517
Locus tag
Dmel_CG14816
See related
AllianceGenome:FB:FBgn0023517
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14816; Dmel\CG14816; dPGAM5; DPGAM5; EG:63B12.4; pgam5; PGAM5
Summary
Enables kinase binding activity; protein serine/threonine kinase activator activity; and protein serine/threonine phosphatase activity. Involved in several processes, including protein dephosphorylation; regulation of mitochondrion organization; and response to anesthetic. Predicted to be located in membrane. Predicted to be active in mitochondrion. Is expressed in adult head and organism. Orthologous to human PGAM5 (PGAM family member 5, mitochondrial serine/threonine protein phosphatase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Pgam5 in Genome Data Viewer
Location:
2B13-2B13; 1-0.2 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1872400..1873565, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1766433..1767598, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Germ cell nuclear acidic peptidase Neighboring gene Mediator complex subunit 18 Neighboring gene Peroxin 5 Neighboring gene uncharacterized protein Neighboring gene Vacuolar protein sorting 26 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PGAM5 is an MFN2 phosphatase that plays an essential role in the regulation of mitochondrial dynamics. Nag S, et al. Cell Rep, 2023 Aug 29. PMID 37498743
  2. Prevention of apoptosis by mitochondrial phosphatase PGAM5 in the mushroom body is crucial for heat shock resistance in Drosophila melanogaster. Ishida Y, et al. PLoS One, 2012. PMID 22347370, Free PMC Article
  3. PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila. Borch Jensen M, et al. Elife, 2017 Sep 11. PMID 28891792, Free PMC Article
  4. Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1. Takeda K, et al. Proc Natl Acad Sci U S A, 2009 Jul 28. PMID 19590015, Free PMC Article
  5. Genetic effects in Drosophila on the potency of diverse general anesthetics: a distinctive pattern of altered sensitivity. Campbell JL, et al. J Neurogenet, 2009. PMID 19863272, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The authors show that developmental mitochondrial unfolded protein response is necessary and sufficient to extend Drosophila lifespan, and identify Phosphoglycerate Mutase 5 (PGAM5) as a mediator of this response. Developmental mitochondrial stress leads to activation of FoxO, via Apoptosis Signal-regulating Kinase 1 (ASK1) and Jun-N-terminal Kinase (JNK).
    Title: PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila.
  2. the mushroom body may possess an apoptosis-dependent toxic function, the suppression of which by dPGAM5 appears to be crucial for heat shock resistance.
    Title: Prevention of apoptosis by mitochondrial phosphatase PGAM5 in the mushroom body is crucial for heat shock resistance in Drosophila melanogaster.
  3. PGAM5 negatively regulates the PINK1 pathway related to maintenance of the mitochondria.
    Title: The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
NOT enables phosphoglycerate mutase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of mitochondrial fission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mitochondrial fission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of mitochondrial fusion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of mitochondrion organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to anesthetic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
phosphoglycerate mutase 5
Names
CG14816-PA
CG14816-PB
Pgam5-PA
Pgam5-PB
NP_001284795.1
NP_569951.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    1872400..1873565 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001297866.1 → NP_001284795.1  phosphoglycerate mutase 5, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284795.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JC94
    Conserved Domains (1) summary
    cd07067
    Location:88 → 264
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

  2. NM_130595.3 → NP_569951.1  phosphoglycerate mutase 5, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_569951.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46084, Q7K2X2
    Related
    FBpp0070350
    Conserved Domains (1) summary
    cd07067
    Location:88 → 265
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O46084.1 O46084
X2JC94 X2JC94

Gene LinkOut

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