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Spef1 sperm flagellar 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311429, updated on 4-Jan-2025

Summary

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Official Symbol
Spef1provided by RGD
Official Full Name
sperm flagellar 1provided by RGD
Primary source
RGD:1311267
See related
AllianceGenome:RGD:1311267
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311267
Summary
Predicted to enable actin binding activity and microtubule binding activity. Predicted to be involved in cilium movement; negative regulation of microtubule depolymerization; and plasma membrane bounded cell projection assembly. Predicted to be located in several cellular components, including basolateral plasma membrane; ciliary tip; and cytoskeleton. Predicted to be active in axoneme. Orthologous to human SPEF1 (sperm flagellar 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 45.2), Lung (RPKM 40.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Spef1 in Genome Data Viewer
Location:
3q36
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (138843679..138849762, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (118390659..118396842, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (123712907..123720787, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene heat shock protein family A (Hsp70) member 12B Neighboring gene adipose secreted signaling protein Neighboring gene centromere protein B Neighboring gene uncharacterized LOC134486156

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CLAMP, a novel microtubule-associated protein with EB-type calponin homology. Dougherty GW, et al. Cell Motil Cytoskeleton, 2005 Nov. PMID 16206169
  2. Spef1, a conserved novel testis protein found in mouse sperm flagella. Chan SW, et al. Gene, 2005 Jul 4. PMID 15979255
  3. Sperm Flagellar 1 Binds Actin in Intestinal Epithelial Cells and Contributes to Formation of Filopodia and Lamellipodia. Tapia R, et al. Gastroenterology, 2019 Dec. PMID 31473225, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC116270

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in axonemal central apparatus assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium movement ISO
Inferred from Sequence Orthology
more info
  
involved_in filopodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule bundle formation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in 9+2 motile cilium ISO
Inferred from Sequence Orthology
more info
  
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in axonemal central apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary tip ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in filopodium ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in microvillus ISO
Inferred from Sequence Orthology
more info
  
located_in motile cilium ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sperm flagellar protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039024.2 → NP_001034113.2  sperm flagellar protein 1

    See identical proteins and their annotated locations for NP_001034113.2

    Status: VALIDATED

    Source sequence(s)
    BC099127
    UniProtKB/TrEMBL
    A6HQC5
    Conserved Domains (1) summary
    pfam06294
    Location:14 → 104
    CH_2; CH-like domain in sperm protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    138843679..138849762 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039105010.2 → XP_038960938.1  sperm flagellar protein 1 isoform X2

    UniProtKB/TrEMBL
    Q4KLL8
    Conserved Domains (1) summary
    pfam06294
    Location:13 → 104
    CH_2; CH-like domain in sperm protein

  2. XM_006235033.5 → XP_006235095.1  sperm flagellar protein 1 isoform X1

    UniProtKB/TrEMBL
    G3V8V9
    Conserved Domains (1) summary
    pfam06294
    Location:14 → 104
    CH_2; CH-like domain in sperm protein

RNA

  1. XR_005501882.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Chemical Information
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