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Stk35 serine/threonine kinase 35 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311419, updated on 27-Nov-2024

Summary

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Official Symbol
Stk35provided by RGD
Official Full Name
serine/threonine kinase 35provided by RGD
Primary source
RGD:1310247
See related
EnsemblRapid:ENSRNOG00000006002 AllianceGenome:RGD:1310247
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Stk35l1
Summary
Predicted to enable eukaryotic translation initiation factor 2alpha kinase activity. Predicted to be involved in regulation of translational initiation. Predicted to be located in nuclear body. Predicted to be active in cytoplasm and nucleus. Orthologous to human STK35 (serine/threonine kinase 35). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 48.9), Adrenal (RPKM 48.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Stk35 in Genome Data Viewer
Location:
3q36
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (137465884..137498554)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (117016819..117049131)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (122307976..122340205)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101661 Neighboring gene prodynorphin Neighboring gene ribosomal protein L22-like 2 Neighboring gene uncharacterized LOC134486151 Neighboring gene ribosomal protein L12, pseudogene 5 Neighboring gene uncharacterized LOC134486152

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identifying and characterizing a novel protein kinase STK35L1 and deciphering its orthologs and close-homologs in vertebrates. Goyal P, et al. PLoS One, 2009 Sep 16. PMID 19756140, Free PMC Article
  2. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of G2/MI transition of meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase 35
NP_001101243.1
XP_006235036.1
XP_006235037.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107773.1 → NP_001101243.1  serine/threonine-protein kinase 35

    See identical proteins and their annotated locations for NP_001101243.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473949
    UniProtKB/TrEMBL
    A6HQ70, D3ZKU3
    Related
    ENSRNOP00000008071.5, ENSRNOT00000008071.7
    Conserved Domains (2) summary
    smart00220
    Location:272 → 593
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13977
    Location:271 → 599
    STKc_PDIK1L; Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    137465884..137498554
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234975.5 → XP_006235037.1  serine/threonine-protein kinase 35 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AKS4
    Related
    ENSRNOP00000093642.1, ENSRNOT00000117385.2
    Conserved Domains (1) summary
    cl21453
    Location:271 → 369
    PKc_like; Protein Kinases, catalytic domain

  2. XM_006234974.5 → XP_006235036.1  serine/threonine-protein kinase 35 isoform X1

    Conserved Domains (2) summary
    smart00220
    Location:70 → 391
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13977
    Location:69 → 397
    STKc_PDIK1L; Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like
Nucleotide Protein Strain
Heading Accession and Version

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