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Anapc1 anaphase promoting complex subunit 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311412, updated on 4-Jan-2025

Summary

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Official Symbol
Anapc1provided by RGD
Official Full Name
anaphase promoting complex subunit 1provided by RGD
Primary source
RGD:1306629
See related
EnsemblRapid:ENSRNOG00000016965 AllianceGenome:RGD:1306629
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable molecular adaptor activity. Predicted to be involved in anaphase-promoting complex-dependent catabolic process; metaphase/anaphase transition of mitotic cell cycle; and protein polyubiquitination. Predicted to be located in nucleus. Predicted to be part of anaphase-promoting complex. Human ortholog(s) of this gene implicated in Rothmund-Thomson syndrome. Orthologous to human ANAPC1 (anaphase promoting complex subunit 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 141.0), Lung (RPKM 122.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Anapc1 in Genome Data Viewer
Location:
3q36
Exon count:
51
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (136303350..136383464, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (115850117..115930259, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (121147484..121226125, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550367 Neighboring gene speedy/RINGO cell cycle regulator family, member E4C Neighboring gene MER proto-oncogene, tyrosine kinase Neighboring gene transmembrane protein 87B Neighboring gene transfer RNA alanine (anticodon AGC) 45

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. Fan M, et al. Genes Dev, 2004 Feb 1. PMID 14744933, Free PMC Article
  2. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. Jin L, et al. Cell, 2008 May 16. PMID 18485873, Free PMC Article
  3. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. Dube P, et al. Mol Cell, 2005 Dec 22. PMID 16364912
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anaphase-promoting complex-dependent catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in metaphase/anaphase transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K11-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein branched polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of anaphase-promoting complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
anaphase-promoting complex subunit 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107771.1 → NP_001101241.1  anaphase-promoting complex subunit 1

    See identical proteins and their annotated locations for NP_001101241.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473949
    UniProtKB/TrEMBL
    A0A8I6A4J8, A6HQ36
    Related
    ENSRNOP00000052727.5, ENSRNOT00000055875.5
    Conserved Domains (2) summary
    pfam01851
    Location:1467 → 1501
    PC_rep; Proteasome/cyclosome repeat
    pfam12859
    Location:150 → 206
    ANAPC1; Anaphase-promoting complex subunit 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    136303350..136383464 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008762177.4 → XP_008760399.1  anaphase-promoting complex subunit 1 isoform X1

    See identical proteins and their annotated locations for XP_008760399.1

    UniProtKB/TrEMBL
    A0A8I6A4J8, A6HQ36
    Conserved Domains (2) summary
    pfam01851
    Location:1467 → 1501
    PC_rep; Proteasome/cyclosome repeat
    pfam12859
    Location:150 → 206
    ANAPC1; Anaphase-promoting complex subunit 1

  2. XM_006234973.5 → XP_006235035.1  anaphase-promoting complex subunit 1 isoform X1

    See identical proteins and their annotated locations for XP_006235035.1

    UniProtKB/TrEMBL
    A0A8I6A4J8, A6HQ36
    Conserved Domains (2) summary
    pfam01851
    Location:1467 → 1501
    PC_rep; Proteasome/cyclosome repeat
    pfam12859
    Location:150 → 206
    ANAPC1; Anaphase-promoting complex subunit 1

  3. XM_063283753.1 → XP_063139823.1  anaphase-promoting complex subunit 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A3X6, F1M801
    Related
    ENSRNOP00000085653.1, ENSRNOT00000111998.2
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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