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Atp8b4 ATPase phospholipid transporting 8B4 (putative) [ Rattus norvegicus (Norway rat) ]

Gene ID: 311396, updated on 27-Nov-2024

Summary

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Official Symbol
Atp8b4provided by RGD
Official Full Name
ATPase phospholipid transporting 8B4 (putative)provided by RGD
Primary source
RGD:1306712
See related
EnsemblRapid:ENSRNOG00000031598 AllianceGenome:RGD:1306712
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and magnesium ion binding activity. Predicted to be involved in lipid translocation and phospholipid transport. Predicted to be located in Golgi apparatus and plasma membrane. Predicted to be part of phospholipid-translocating ATPase complex. Orthologous to human ATP8B4 (ATPase phospholipid transporting 8B4 (putative)). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 60.5), Lung (RPKM 40.0) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Atp8b4 in Genome Data Viewer
Location:
3q36
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (134008367..134212394, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (113554979..113757635, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (118591560..118968210, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 227, member B Neighboring gene fibroblast growth factor 7 Neighboring gene DTW domain containing 1 Neighboring gene U6 spliceosomal RNA Neighboring gene solute carrier family 27 member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases. van der Velden LM, et al. J Biol Chem, 2010 Dec 17. PMID 20947505, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC114491

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled intramembrane lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase-coupled intramembrane lipid transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid translocation IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
part_of phospholipid-translocating ATPase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable phospholipid-transporting ATPase IM
Names
ATPase, class I, type 8B, member 4
XP_038962769.1
XP_038962770.1
XP_038962771.1
XP_038962772.1
XP_038962774.1
XP_038962775.1
XP_038962776.1
XP_038962778.1
XP_038962779.1
XP_063141379.1
XP_063141380.1
XP_063141382.1
XP_063141383.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001430434.1 → NP_001417363.1  probable phospholipid-transporting ATPase IM

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A1B0GWR9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    134008367..134212394 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039106842.2 → XP_038962770.1  probable phospholipid-transporting ATPase IM isoform X1

    Related
    ENSRNOP00000075998.2, ENSRNOT00000092750.3
    Conserved Domains (1) summary
    cd02073
    Location:31 → 975
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

  2. XM_063285310.1 → XP_063141380.1  probable phospholipid-transporting ATPase IM isoform X2

  3. XM_039106844.2 → XP_038962772.1  probable phospholipid-transporting ATPase IM isoform X1

    UniProtKB/TrEMBL
    A0A1B0GWR9
    Conserved Domains (1) summary
    cd02073
    Location:31 → 975
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

  4. XM_039106846.2 → XP_038962774.1  probable phospholipid-transporting ATPase IM isoform X2

    Conserved Domains (1) summary
    cd02073
    Location:31 → 937
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

  5. XM_039106847.2 → XP_038962775.1  probable phospholipid-transporting ATPase IM isoform X3

    Conserved Domains (1) summary
    cd02073
    Location:31 → 920
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

  6. XM_039106841.2 → XP_038962769.1  probable phospholipid-transporting ATPase IM isoform X1

    UniProtKB/TrEMBL
    A0A1B0GWR9
    Conserved Domains (1) summary
    cd02073
    Location:31 → 975
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

  7. XM_063285309.1 → XP_063141379.1  probable phospholipid-transporting ATPase IM isoform X2

  8. XM_039106843.2 → XP_038962771.1  probable phospholipid-transporting ATPase IM isoform X1

    UniProtKB/TrEMBL
    A0A1B0GWR9
    Conserved Domains (1) summary
    cd02073
    Location:31 → 975
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

  9. XM_063285312.1 → XP_063141382.1  probable phospholipid-transporting ATPase IM isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZYK3

  10. XM_039106848.1 → XP_038962776.1  probable phospholipid-transporting ATPase IM isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZYK3
    Conserved Domains (1) summary
    cd02073
    Location:3 → 859
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

  11. XM_039106851.1 → XP_038962779.1  probable phospholipid-transporting ATPase IM isoform X6

    UniProtKB/TrEMBL
    A6HPY3
    Conserved Domains (1) summary
    cl21460
    Location:14 → 520
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  12. XM_063285313.1 → XP_063141383.1  probable phospholipid-transporting ATPase IM isoform X7

  13. XM_039106850.2 → XP_038962778.1  probable phospholipid-transporting ATPase IM isoform X5

    Conserved Domains (1) summary
    cl21460
    Location:31 → 707
    HAD_like; Haloacid Dehalogenase-like Hydrolases

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001025690.1: Suppressed sequence

    Description
    NM_001025690.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
Nucleotide Protein Strain
Heading Accession and Version

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