Rab27 Rab27 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rab27provided by FlyBase
Official Full Name: Rab27provided by FlyBase
Primary source: FLYBASE:FBgn0025382
Locus tag: Dmel_CG14791
See related: AllianceGenome:FB:FBgn0025382
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 18543235; AAF45634; AAF45635; CG14791; dm-Rab27; Dmel\CG14791; DmRab27; EG:80H7.4; O76901; rab27
Summary: Predicted to enable GTP binding activity and GTPase activity. Involved in exosomal secretion. Located in synaptic vesicle. Is expressed in several structures, including Bolwig organ; brain; lamina; larval ventral nerve cord; and mushroom body. Human ortholog(s) of this gene implicated in Griscelli syndrome type 2 and non-Langerhans-cell histiocytosis. Orthologous to several human genes including RAB27A (RAB27A, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (1473884..1476974, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (1367917..1371007, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Lifespan regulation in alpha/beta posterior neurons of the fly mushroom bodies by Rab27.
Title: Lifespan regulation in α/β posterior neurons of the fly mushroom bodies by Rab27.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Rab protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in exosomal secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in exocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	HDA more info	PubMed
located_in synaptic vesicle	HDA more info	PubMed
located_in vesicle	ISS Inferred from Sequence or Structural Similarity more info

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The following sections contain reference sequences that belong to a specific genome build. Explain