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pck pickel [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31101, updated on 9-Dec-2024

Summary

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Official Symbol
pckprovided by FlyBase
Official Full Name
pickelprovided by FlyBase
Primary source
FLYBASE:FBgn0013720
Locus tag
Dmel_CG14779
See related
AllianceGenome:FB:FBgn0013720
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14779; Dmel\CG14779; EG:80H7.2; l(1)G0044; mega; Mega; Pck; PCK
Summary
Involved in establishment of glial blood-brain barrier; open tracheal system development; and septate junction assembly. Located in septate junction. Is expressed in organism. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See pck in Genome Data Viewer
Location:
2A4-2A4; 1-0.2 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1470666..1472325)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1364699..1366358)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rab27

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TEV protease-mediated cleavage in Drosophila as a tool to analyze protein functions in living organisms. Harder B, et al. Biotechniques, 2008 May. PMID 18476830
  2. The claudin Megatrachea protein complex. Jaspers MH, et al. J Biol Chem, 2012 Oct 26. PMID 22930751, Free PMC Article
  3. Fluorescent fusion protein knockout mediated by anti-GFP nanobody. Caussinus E, et al. Nat Struct Mol Biol, 2011 Dec 11. PMID 22157958
  4. The fatty acyl-CoA reductase Waterproof mediates airway clearance in Drosophila. Jaspers MH, et al. Dev Biol, 2014 Jan 1. PMID 24183938
  5. The Drosophila stubarista phenotype is associated with a dosage effect of the putative ribosome-associated protein D-p40 on spineless. Melnick MB, et al. Genetics, 1993 Oct. PMID 7916731, Free PMC Article

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in establishment of glial blood-brain barrier IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in liquid clearance, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in open tracheal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of tube size, open tracheal system IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of tube size, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in septate junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in septate junction assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in septate junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in septate junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in septate junction ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
pickel
Names
CG14779-PA
CG14779-PC
CG14779-PD
megatrachea
pck-PA
pck-PC
pck-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    1470666..1472325
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166887.3 → NP_726742.1  pickel, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726742.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E4NKM0, O76899
    Related
    FBpp0070245
    Conserved Domains (1) summary
    cl21598
    Location:39 → 211
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

  2. NM_001038731.1 → NP_001033820.1  pickel, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001033820.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2PE37
    Conserved Domains (1) summary
    cl21598
    Location:39 → 92
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

  3. NM_130563.4 → NP_569919.2  pickel, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_569919.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E4NKM0, O76899
    Related
    FBpp0070246
    Conserved Domains (1) summary
    cl21598
    Location:39 → 211
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O76899 O76899
Q2PE37 Q2PE37
Q8T098 Q8T098

Gene LinkOut

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