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Fpgt fucose-1-phosphate guanylyltransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 310935, updated on 4-Jan-2025

Summary

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Official Symbol
Fpgtprovided by RGD
Official Full Name
fucose-1-phosphate guanylyltransferaseprovided by RGD
Primary source
RGD:735121
See related
EnsemblRapid:ENSRNOG00000009548 AllianceGenome:RGD:735121
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable fucose-1-phosphate guanylyltransferase activity. Predicted to be involved in GDP-L-fucose salvage and L-fucose metabolic process. Orthologous to human FPGT (fucose-1-phosphate guanylyltransferase). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 64.8), Liver (RPKM 44.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fpgt in Genome Data Viewer
Location:
2q45
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (246757982..246778896, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (244099031..244119967, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (261382015..261402950, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta, pseudogene 3 Neighboring gene TNNI3 interacting kinase Neighboring gene leucine rich repeat containing 53 Neighboring gene leucine-rich repeats and IQ motif containing 3 Neighboring gene uncharacterized LOC134486009 Neighboring gene ribosomal protein L32, pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. GDP-L-fucose pyrophosphorylase. Purification, cDNA cloning, and properties of the enzyme. Pastuszak I, et al. J Biol Chem, 1998 Nov 13. PMID 9804772
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables fucose-1-phosphate guanylyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in GDP-L-fucose salvage ISO
Inferred from Sequence Orthology
more info
  
involved_in L-fucose metabolic process ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
fucose-1-phosphate guanylyltransferase
Names
gdp-L-fucose pyrophosphorylase
NP_001376152.1
NP_955788.2
XP_038958413.1
XP_038958416.1
XP_063138050.1
XP_063138051.1
XP_063138052.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001389223.1 → NP_001376152.1  fucose-1-phosphate guanylyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    Q5I0Q1
    Related
    ENSRNOP00000074607.1, ENSRNOT00000077839.3
    Conserved Domains (1) summary
    PRK13412
    Location:63 → 107
    fkp; bifunctional fucokinase/L-fucose-1-P-guanylyltransferase; Provisional

  2. NM_199494.2 → NP_955788.2  fucose-1-phosphate guanylyltransferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A0G2K0C0, A6HWQ9, B4F7E4
    Related
    ENSRNOP00000071383.1, ENSRNOT00000088561.3
    Conserved Domains (1) summary
    pfam07959
    Location:106 → 524
    Fucokinase; L-fucokinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    246757982..246778896 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281982.1 → XP_063138052.1  fucose-1-phosphate guanylyltransferase isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZJ53

  2. XM_063281981.1 → XP_063138051.1  fucose-1-phosphate guanylyltransferase isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZPW3

  3. XM_039102488.2 → XP_038958416.1  fucose-1-phosphate guanylyltransferase isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZJ53
    Conserved Domains (1) summary
    PRK13412
    Location:63 → 113
    fkp; bifunctional fucokinase/L-fucose-1-P-guanylyltransferase; Provisional

  4. XM_039102485.2 → XP_038958413.1  fucose-1-phosphate guanylyltransferase isoform X1

    Conserved Domains (1) summary
    pfam07959
    Location:1 → 390
    Fucokinase; L-fucokinase

  5. XM_063281980.1 → XP_063138050.1  fucose-1-phosphate guanylyltransferase isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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