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Frrs1 ferric-chelate reductase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 310810, updated on 9-Dec-2024

Summary

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Official Symbol
Frrs1provided by RGD
Official Full Name
ferric-chelate reductase 1provided by RGD
Primary source
RGD:1306883
See related
EnsemblRapid:ENSRNOG00000016351 AllianceGenome:RGD:1306883
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sdfr2
Summary
Predicted to enable oxidoreductase activity, acting on metal ions. Predicted to be involved in intracellular iron ion homeostasis. Predicted to be active in membrane. Orthologous to human FRRS1 (ferric chelate reductase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Liver (RPKM 156.3), Spleen (RPKM 69.9) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Frrs1 in Genome Data Viewer
Location:
2q42
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (207505786..207566376)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (204820898..204881487)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (220415568..220469559)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100926 Neighboring gene amylo-alpha-1,6-glucosidase and 4-alpha-glucanotransferase Neighboring gene uncharacterized LOC102548573 Neighboring gene uncharacterized LOC102548639 Neighboring gene palmdelphin Neighboring gene phospholipid phosphatase related 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Stromal cell-derived receptor 2 and cytochrome b561 are functional ferric reductases. Vargas JD, et al. Biochim Biophys Acta, 2003 Sep 23. PMID 14499595
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on metal ions IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity, acting on metal ions ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in intracellular iron ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ferric-chelate reductase 1
Names
stromal cell derived factor receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398971.2 → NP_001385900.1  ferric-chelate reductase 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I6AH47
    Related
    ENSRNOP00000092222.2, ENSRNOT00000106832.2
    Conserved Domains (3) summary
    cd08760
    Location:320 → 533
    Cyt_b561_FRRS1_like; Eukaryotic cytochrome b(561), including the FRRS1 gene product
    cd09628
    Location:192 → 354
    DOMON_SDR_2_like; DOMON domain of stromal cell-derived receptor 2 (ferric chelate reductase 1) and related proteins
    pfam02014
    Location:32 → 155
    Reeler; Reeler domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    207505786..207566376
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039103831.2 → XP_038959759.1  ferric-chelate reductase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AH47
    Conserved Domains (3) summary
    cd08760
    Location:320 → 533
    Cyt_b561_FRRS1_like; Eukaryotic cytochrome b(561), including the FRRS1 gene product
    cd09628
    Location:192 → 354
    DOMON_SDR_2_like; DOMON domain of stromal cell-derived receptor 2 (ferric chelate reductase 1) and related proteins
    pfam02014
    Location:32 → 155
    Reeler; Reeler domain

  2. XM_039103832.2 → XP_038959760.1  ferric-chelate reductase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AH47
    Related
    ENSRNOP00000021989.8, ENSRNOT00000021988.9
    Conserved Domains (3) summary
    cd08760
    Location:320 → 533
    Cyt_b561_FRRS1_like; Eukaryotic cytochrome b(561), including the FRRS1 gene product
    cd09628
    Location:192 → 354
    DOMON_SDR_2_like; DOMON domain of stromal cell-derived receptor 2 (ferric chelate reductase 1) and related proteins
    pfam02014
    Location:32 → 155
    Reeler; Reeler domain
Nucleotide Protein Strain
Heading Accession and Version

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