MTPAP mitochondrial poly(A) polymerase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: MTPAPprovided by FlyBase
Official Full Name: mitochondrial poly(A) polymeraseprovided by FlyBase
Primary source: FLYBASE:FBgn0024360
Locus tag: Dmel_CG11418
See related: AllianceGenome:FB:FBgn0024360
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11418; Dmel\CG11418; dmmtpap; DmMTPAP; DmNP_569904; EG:8D8.8; SD27341p; TUTase1
Summary: Enables poly(A) RNA polymerase activity. Involved in mitochondrial mRNA 3'-end processing; mitochondrial mRNA polyadenylation; and tRNA stabilization. Located in mitochondrion. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut; embryonic/larval midgut primordium; and posterior endoderm. Human ortholog(s) of this gene implicated in spastic ataxia 4. Orthologous to human MTPAP (mitochondrial poly(A) polymerase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 1F4-1F4; 1-0.1 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (1344872..1349357, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (1238905..1243390, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

loss of MTPAP leads to reduced steady-state levels and disturbed maturation of tRNACys, indicating that polyadenylation in mitochondria might be important for the stability and maturation of specific tRNAs
Title: Mitochondrial Polyadenylation Is a One-Step Process Required for mRNA Integrity and tRNA Maturation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables poly(A) RNA polymerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables poly(A) RNA polymerase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA 3'-end processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial mRNA 3'-end processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial mRNA polyadenylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial mRNA polyadenylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA stabilization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: mitochondrial poly(A) polymerase

Names: 3' terminal uridylyl transferase 1; CG11418-PA; CG11418-PB; CG11418-PC; MTPAP-PA; MTPAP-PB; MTPAP-PC

NP_001259129.1

EC 2.7.7.19

NP_569904.1

EC 2.7.7.19

NP_996325.1

EC 2.7.7.19

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

1344872..1349357 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001272200.1 → NP_001259129.1 mitochondrial poly(A) polymerase, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259129.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O46102, O46103, Q8MRT1

Conserved Domains (2) summary

cd05402
Location:193 → 333

NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases

pfam03828
Location:427 → 477

PAP_assoc; Cid1 family poly A polymerase
NM_130548.3 → NP_569904.1 mitochondrial poly(A) polymerase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_569904.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O46102, O46103, Q8MRT1

Related

FBpp0070227

Conserved Domains (2) summary

cd05402
Location:193 → 333

NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases

pfam03828
Location:427 → 477

PAP_assoc; Cid1 family poly A polymerase
NM_206602.2 → NP_996325.1 mitochondrial poly(A) polymerase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996325.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KW16

Conserved Domains (1) summary

pfam03828
Location:103 → 153

PAP_assoc; Cid1 family poly A polymerase