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Bcl9 BCL9, transcription coactivator [ Rattus norvegicus (Norway rat) ]

Gene ID: 310704, updated on 4-Jan-2025

Summary

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Official Symbol
Bcl9provided by RGD
Official Full Name
BCL9, transcription coactivatorprovided by RGD
Primary source
RGD:1306934
See related
EnsemblRapid:ENSRNOG00000017516 AllianceGenome:RGD:1306934
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable beta-catenin binding activity. Predicted to be involved in canonical Wnt signaling pathway and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including myotube differentiation involved in skeletal muscle regeneration; skeletal muscle cell differentiation; and somatic stem cell population maintenance. Predicted to be located in cis-Golgi network; nucleus; and sarcoplasm. Predicted to be part of beta-catenin-TCF complex. Orthologous to human BCL9 (BCL9 transcription coactivator). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Lung (RPKM 22.2), Kidney (RPKM 19.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Bcl9 in Genome Data Viewer
Location:
2q34
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (187449425..187475241, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (184760616..184846261, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (199334644..199420083, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene RAD9-HUS1-RAD1 interacting nuclear orphan 1, pseudogene 2 Neighboring gene acid phosphatase 6, lysophosphatidic Neighboring gene proline-rich protein 2-like Neighboring gene uncharacterized LOC102549654 Neighboring gene uncharacterized LOC102550046

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TMF/ARA160: A key regulator of sperm development. Lerer-Goldshtein T, et al. Dev Biol, 2010 Dec 1. PMID 20691678
  2. Bcl9/Bcl9l are critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas. Deka J, et al. Cancer Res, 2010 Aug 15. PMID 20682801
  3. BCL9 is an essential component of canonical Wnt signaling that mediates the differentiation of myogenic progenitors during muscle regeneration. Brack AS, et al. Dev Biol, 2009 Nov 1. PMID 19699733, Free PMC Article
  4. A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential. Fritzmann J, et al. Gastroenterology, 2009 Jul. PMID 19328798
  5. Role of a BCL9-related beta-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling. Adachi S, et al. Cancer Res, 2004 Dec 1. PMID 15574752

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within myoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within myotube differentiation involved in skeletal muscle regeneration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within skeletal muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within somatic stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
part_of beta-catenin-TCF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of beta-catenin-TCF complex ISO
Inferred from Sequence Orthology
more info
  
located_in cis-Golgi network ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in sarcoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
B-cell CLL/lymphoma 9 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107703.4 → NP_001101173.2  B-cell CLL/lymphoma 9 protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I6GB32, D4A7D6
    Related
    ENSRNOP00000084827.1, ENSRNOT00000112871.2
    Conserved Domains (2) summary
    PHA03247
    Location:570 → 1160
    PHA03247; large tegument protein UL36; Provisional
    pfam11502
    Location:350 → 388
    BCL9; B-cell lymphoma 9 protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    187449425..187475241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233015.5 → XP_006233077.1  B-cell CLL/lymphoma 9 protein isoform X2

    UniProtKB/TrEMBL
    D4A7D6
    Conserved Domains (2) summary
    pfam04959
    Location:1016 → 1107
    ARS2; Arsenite-resistance protein 2
    pfam11502
    Location:276 → 314
    BCL9; B-cell lymphoma 9 protein

  2. XM_006233014.5 → XP_006233076.1  B-cell CLL/lymphoma 9 protein isoform X1

    UniProtKB/TrEMBL
    D4A7D6
    Conserved Domains (2) summary
    pfam04959
    Location:1078 → 1169
    ARS2; Arsenite-resistance protein 2
    pfam11502
    Location:350 → 388
    BCL9; B-cell lymphoma 9 protein
Nucleotide Protein Strain
Heading Accession and Version

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