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Fcrl2 Fc receptor-like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 310694, updated on 27-Nov-2024

Summary

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Official Symbol
Fcrl2provided by RGD
Official Full Name
Fc receptor-like 2provided by RGD
Primary source
RGD:1306885
See related
EnsemblRapid:ENSRNOG00000016164 AllianceGenome:RGD:1306885
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Msr2; Fcrls
Summary
Predicted to enable protein phosphatase binding activity; signaling adaptor activity; and transmembrane signaling receptor activity. Predicted to be involved in cell surface receptor signaling pathway and immune response. Predicted to be located in cell surface. Predicted to be active in external side of plasma membrane. Orthologous to human FCRL2 (Fc receptor like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Uterus (RPKM 118.5), Brain (RPKM 81.4) and 8 other tissues See more
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Genomic context

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See Fcrl2 in Genome Data Viewer
Location:
2q34
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (174992226..175005177, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (172694308..172707261, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (186594442..186605115, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene kirre like nephrin family adhesion molecule 1 Neighboring gene uncharacterized LOC134485634 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene elongator acetyltransferase complex subunit 4, pseudogene 1 Neighboring gene Cd5 molecule-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of six novel mutations in the methylenetetrahydrofolate reductase (MTHFR) gene in patients with homocystinuria. Sibani S, et al. Hum Mutat, 2000. PMID 10679944
  2. Molecular cloning and characterization of SPAP1, an inhibitory receptor. Xu MJ, et al. Biochem Biophys Res Commun, 2001 Jan 26. PMID 11162587
  3. Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia. Polson AG, et al. Int Immunol, 2006 Sep. PMID 16849395
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Fc receptor-like 2
Names
Fc receptor-like S, scavenger receptor
macrophage scavenger receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107702.1 → NP_001101172.1  Fc receptor-like 2 precursor

    See identical proteins and their annotated locations for NP_001101172.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473976
    UniProtKB/TrEMBL
    A6J602, F1M652
    Related
    ENSRNOP00000021938.6, ENSRNOT00000021938.7
    Conserved Domains (5) summary
    smart00202
    Location:402 → 502
    SR; Scavenger receptor Cys-rich
    smart00409
    Location:224 → 304
    IG; Immunoglobulin
    pfam13927
    Location:122 → 181
    Ig_3; Immunoglobulin domain
    cd00096
    Location:19 → 23
    Ig; Ig strand A [structural motif]
    cl11960
    Location:19 → 85
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    174992226..175005177 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102396.2 → XP_038958324.1  Fc receptor-like 2 isoform X1

    UniProtKB/TrEMBL
    A6J602, F1M652
    Conserved Domains (5) summary
    smart00202
    Location:402 → 502
    SR; Scavenger receptor Cys-rich
    smart00409
    Location:224 → 304
    IG; Immunoglobulin
    pfam13927
    Location:122 → 181
    Ig_3; Immunoglobulin domain
    cd00096
    Location:19 → 23
    Ig; Ig strand A [structural motif]
    cl11960
    Location:19 → 85
    Ig; Immunoglobulin domain

  2. XM_039102397.2 → XP_038958325.1  Fc receptor-like 2 isoform X1

    UniProtKB/TrEMBL
    A6J602, F1M652
    Conserved Domains (5) summary
    smart00202
    Location:402 → 502
    SR; Scavenger receptor Cys-rich
    smart00409
    Location:224 → 304
    IG; Immunoglobulin
    pfam13927
    Location:122 → 181
    Ig_3; Immunoglobulin domain
    cd00096
    Location:19 → 23
    Ig; Ig strand A [structural motif]
    cl11960
    Location:19 → 85
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version

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