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Ppm1l protein phosphatase, Mg2+/Mn2+ dependent, 1L [ Rattus norvegicus (Norway rat) ]

Gene ID: 310506, updated on 27-Nov-2024

Summary

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Official Symbol
Ppm1lprovided by RGD
Official Full Name
protein phosphatase, Mg2+/Mn2+ dependent, 1Lprovided by RGD
Primary source
RGD:1305220
See related
EnsemblRapid:ENSRNOG00000075763 AllianceGenome:RGD:1305220
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within MAPK cascade and cell surface receptor protein serine/threonine kinase signaling pathway. Orthologous to human PPM1L (protein phosphatase, Mg2+/Mn2+ dependent 1L). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 125.5), Uterus (RPKM 105.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ppm1l in Genome Data Viewer
Location:
2q32
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (155876605..156149371)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (153566653..153839434)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (165932240..166218774)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ARF like GTPase 14 Neighboring gene protein phosphatase 1, regulatory subunit 3b, pseudogene 2 Neighboring gene ubiquitin-like modifier activating enzyme 3, pseudogene 1 Neighboring gene beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) Neighboring gene uncharacterized LOC134485628 Neighboring gene ATPase H+ transporting V1 subunit A, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The dynamic expression of tenascin-C and tenascin-X during early heart development in the mouse. Imanaka-Yoshida K, et al. Differentiation, 2003 Jun. PMID 12823230
  2. Protein phosphatase 2Cepsilon is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes. Saito S, et al. J Biol Chem, 2008 Mar 7. PMID 18165232
  3. Regulation of the interleukin-1-induced signaling pathways by a novel member of the protein phosphatase 2C family (PP2Cepsilon). Li MG, et al. J Biol Chem, 2003 Apr 4. PMID 12556533
  4. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CERT is a physiological substrate of PP2Cepsilon and that dephosphorylation of CERT by PP2Cepsilon may play an important role in the regulation of ceramide trafficking from the ER to the Golgi apparatus.
    Title: Protein phosphatase 2Cepsilon is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein phosphatase 1L
NP_001101151.1
XP_017446354.1
XP_038958215.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107681.4 → NP_001101151.1  protein phosphatase 1L

    See identical proteins and their annotated locations for NP_001101151.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I5ZU99, A6J5N2
    Related
    ENSRNOP00000112533.1, ENSRNOT00000129498.1
    Conserved Domains (1) summary
    cd00143
    Location:93 → 351
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    155876605..156149371
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102287.2 → XP_038958215.1  protein phosphatase 1L isoform X2

    Conserved Domains (1) summary
    cd00143
    Location:12 → 172
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

  2. XM_017590865.3 → XP_017446354.1  protein phosphatase 1L isoform X1

    UniProtKB/TrEMBL
    A0A8I6A4H5
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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