MED22 Mediator complex subunit 22 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: MED22provided by FlyBase
Official Full Name: Mediator complex subunit 22provided by FlyBase
Primary source: FLYBASE:FBgn0040339
Locus tag: Dmel_CG3034
See related: AllianceGenome:FB:FBgn0040339
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 144358_at; anon-EST:Liang-1.82; CG18830; CG3034; clone 1.82; dMED24; Dmel\CG3034; EG:BACR7A4.6; med22; Med22; Med24; Srb6/Surf5
Summary: Predicted to contribute to transcription coregulator activity. Involved in regulation of transcription by RNA polymerase II. Located in chromatin and nucleolus. Part of mediator complex. Is expressed in organism. Orthologous to human MED22 (mediator complex subunit 22). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (928139..928860)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (822172..822893)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

The Mediator subunit Med22 binds the tMAC component Topi when the two are coexpressed in S2 cells, suggesting direct recruitment.
Title: Recruitment of Mediator Complex by Cell Type and Stage-Specific Factors Required for Tissue-Specific TAF Dependent Gene Activation in an Adult Stem Cell Lineage.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to transcription coregulator activity	IC Inferred by Curator more info	PubMed
enables transcription coregulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitotic cell cycle	HMP more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IC Inferred by Curator more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
part_of mediator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mediator complex	IDA Inferred from Direct Assay more info	PubMed
part_of mediator complex	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain