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Zfp131 zinc finger protein 131 [ Rattus norvegicus (Norway rat) ]

Gene ID: 310375, updated on 27-Nov-2024

Summary

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Official Symbol
Zfp131provided by RGD
Official Full Name
zinc finger protein 131provided by RGD
Primary source
RGD:1307638
See related
EnsemblRapid:ENSRNOG00000015925 AllianceGenome:RGD:1307638
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of gene expression and regulation of immune system process. Predicted to be located in intermediate filament cytoskeleton. Predicted to be active in nucleoplasm. Orthologous to human ZNF131 (zinc finger protein 131). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 150.5), Spleen (RPKM 108.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zfp131 in Genome Data Viewer
Location:
2q15-q16
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (53457893..53486348, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (51722774..51753662, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (52503185..52532097, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547360 Neighboring gene 3-hydroxy-3-methylglutaryl-CoA synthase 1 Neighboring gene NIM1 serine/threonine protein kinase Neighboring gene uncharacterized LOC134485849 Neighboring gene RNA, U6 small nuclear 446 Neighboring gene zinc finger protein 131 like 1 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 4, pseudogene 3 Neighboring gene uncharacterized LOC134485779

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Kaiso regulates Znf131-mediated transcriptional activation. Donaldson NS, et al. Exp Cell Res, 2010 Jun 10. PMID 20303951
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 131

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100698.2 → NP_001094168.1  zinc finger protein 131

    See identical proteins and their annotated locations for NP_001094168.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    B1WC22, F7FPM3
    Related
    ENSRNOP00000021608.4, ENSRNOT00000021608.8
    Conserved Domains (6) summary
    smart00225
    Location:35 → 122
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:262 → 444
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:290 → 311
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:422 → 439
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:24 → 122
    BTB; BTB/POZ domain
    pfam13465
    Location:342 → 367
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    53457893..53486348 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281778.1 → XP_063137848.1  zinc finger protein 131 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JX21, A6I5X1

  2. XM_006231960.5 → XP_006232022.1  zinc finger protein 131 isoform X1

    See identical proteins and their annotated locations for XP_006232022.1

    UniProtKB/TrEMBL
    B1WC22, F7FPM3
    Conserved Domains (6) summary
    smart00225
    Location:35 → 122
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:262 → 444
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:290 → 311
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:422 → 439
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:24 → 122
    BTB; BTB/POZ domain
    pfam13465
    Location:342 → 367
    zf-H2C2_2; Zinc-finger double domain

  3. XM_063281781.1 → XP_063137851.1  zinc finger protein 131 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JX21, A6I5X1

  4. XM_006231963.5 → XP_006232025.1  zinc finger protein 131 isoform X1

    See identical proteins and their annotated locations for XP_006232025.1

    UniProtKB/TrEMBL
    B1WC22, F7FPM3
    Conserved Domains (6) summary
    smart00225
    Location:35 → 122
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:262 → 444
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:290 → 311
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:422 → 439
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:24 → 122
    BTB; BTB/POZ domain
    pfam13465
    Location:342 → 367
    zf-H2C2_2; Zinc-finger double domain

  5. XM_063281780.1 → XP_063137850.1  zinc finger protein 131 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JX21, A6I5X1
    Related
    ENSRNOP00000070103.1, ENSRNOT00000089303.3

  6. XM_006231962.5 → XP_006232024.1  zinc finger protein 131 isoform X1

    See identical proteins and their annotated locations for XP_006232024.1

    UniProtKB/TrEMBL
    B1WC22, F7FPM3
    Conserved Domains (6) summary
    smart00225
    Location:35 → 122
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:262 → 444
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:290 → 311
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:422 → 439
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:24 → 122
    BTB; BTB/POZ domain
    pfam13465
    Location:342 → 367
    zf-H2C2_2; Zinc-finger double domain

  7. XM_063281779.1 → XP_063137849.1  zinc finger protein 131 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JX21, A6I5X1

  8. XM_006231961.5 → XP_006232023.1  zinc finger protein 131 isoform X1

    See identical proteins and their annotated locations for XP_006232023.1

    UniProtKB/TrEMBL
    B1WC22, F7FPM3
    Conserved Domains (6) summary
    smart00225
    Location:35 → 122
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:262 → 444
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:290 → 311
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:422 → 439
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:24 → 122
    BTB; BTB/POZ domain
    pfam13465
    Location:342 → 367
    zf-H2C2_2; Zinc-finger double domain

  9. XM_063281782.1 → XP_063137852.1  zinc finger protein 131 isoform X3

  10. XM_039102253.2 → XP_038958181.1  zinc finger protein 131 isoform X4

    Conserved Domains (3) summary
    sd00017
    Location:11 → 32
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:143 → 160
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:63 → 88
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

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