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Eif5a2 eukaryotic translation initiation factor 5A2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 310261, updated on 4-Jan-2025

Summary

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Official Symbol
Eif5a2provided by RGD
Official Full Name
eukaryotic translation initiation factor 5A2provided by RGD
Primary source
RGD:1306196
See related
EnsemblRapid:ENSRNOG00000011859 AllianceGenome:RGD:1306196
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
eIF5AII
Summary
Predicted to enable translation elongation factor activity. Predicted to be involved in translational elongation. Predicted to be located in intracellular membrane-bounded organelle. Orthologous to human EIF5A2 (eukaryotic translation initiation factor 5A2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 187.3), Testes (RPKM 69.6) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Eif5a2 in Genome Data Viewer
Location:
2q24
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (113656748..113674598)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (111728587..111746087)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (115336646..115354203)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene TRAF2 and NCK interacting kinase Neighboring gene uncharacterized LOC134485609 Neighboring gene solute carrier family 2 member 2 Neighboring gene ribosomal protein L22 like 1 Neighboring gene uncharacterized LOC134485729

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability. Chen M, et al. BMC Cancer, 2011 May 26. PMID 21612665, Free PMC Article
  2. Identification and characterization of eukaryotic initiation factor 5A-2. Clement PM, et al. Eur J Biochem, 2003 Nov. PMID 14622290
  3. Human eIF5A2 on chromosome 3q25-q27 is a phylogenetically conserved vertebrate variant of eukaryotic translation initiation factor 5A with tissue-specific expression. Jenkins ZA, et al. Genomics, 2001 Jan 1. PMID 11161802
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
  
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in positive regulation of translational elongation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of translational termination IEA
Inferred from Electronic Annotation
more info
  
involved_in translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 5A-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100697.3 → NP_001094167.1  eukaryotic translation initiation factor 5A-2

    See identical proteins and their annotated locations for NP_001094167.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A6IHJ3, G3V7J7
    Related
    ENSRNOP00000015779.5, ENSRNOT00000015779.9
    Conserved Domains (1) summary
    cl30809
    Location:1 → 150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    113656748..113674598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232231.5 → XP_006232293.1  eukaryotic translation initiation factor 5A-2 isoform X1

    See identical proteins and their annotated locations for XP_006232293.1

    UniProtKB/TrEMBL
    A6IHJ3, G3V7J7
    Conserved Domains (1) summary
    cl30809
    Location:1 → 150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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